The Pitt laboratory is seeking a motivated junior postdoctoral fellow to join our dynamic team (https://medicine.yale.edu/lab/pitt/). We conduct translational research centered on mechanisms that underlie progression/neurodegeneration in multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), focusing in particular on glial cells. We are using cutting-edge technologies such as multiomic single nucleus profiling (DOGMA-Seq), and highly multiplexed histological imaging of brain tissue sections and their integration with advanced computational tools. The PI is a co-director of the National MS Brain Bank, and the laboratory is embedded in a highly collaborative, translational neuroimmunology program that includes genetics and computational biology.
The successful candidate will drive a project involving astrocyte-specific exosomes isolated from plasma, CSF and brain tissue of patients with progressive MS and other neurodegenerative diseases to develop biomarkers for neurodegeneration. We have established a robust protocol for isolation of astrocyte-specific exosomes and for profiling of exosomal miRNA content on which the candidate can build.
We are looking for applicants with a broad background in neurobiology and good publication record, that are willing to work in a highly collaborative environment to support ongoing projects, design and execute research projects in consultation with the PI, and help prepare manuscripts, presentations, and grant applications. Expertise in the exosome field is highly desirable but not necessary.
Please respond with a statement of interest, CV, a short description of relevant expertise, as well as three references to firstname.lastname@example.org. The position is NIH funded for a minimum of 2 years and can be filled as early as 12/2023.