In the lab of Dr. Raghu Vemuganti, Professor and Vice-Chair for Basic Research, Dept. of Neurological Surgery, Univ. of Wisconsin. The lab is supported by several federally funded (NIH and VA) grants.
Focus: To investigate the role of noncoding RNAs (microRNAs, lncRNAs and circRNAs), epigenetics, and epitranscriptomics in post-stroke brain damage. Proficiency in rodent stroke models, behavioral analysis, molecular and cellular techniques including histopathology, immunohistochemistry, Western blotting, PCR, RNA-seq and siRNA work is desirable. Skills in data analysis, bioinformatics and writing are helpful. Scientific integrity and understanding of research ethics are of paramount importance to work in this lab.
PhD in neuroscience or biomedical sciences and proficiency in English are required. The incumbent is expected to interact with several scientists, post-docs, and grad students working in Vemuganti Lab.
If interested, submit CV, a brief cover letter indicating prior research experience, career goals and names of 2 referees to firstname.lastname@example.org.
University of Wisconsin (Madison, WI, USA) is one of the Big-10 universities with intense biomedical research. Madison is a top place to live in the US. The University of Wisconsin is an equal opportunity employer and encourages applications from underrepresented groups and women.
Representative publications from the lab:
Mehta SL, Chokkalla AK, Bathula S, Arruri V, Chelluboina B, Vemuganti R (2023) CDR1as regulates ischemic brain damage by controlling miR-7 availability. Molecular Therapy Nucleic Acids 31:57-67.
Chokkalla AK, Jeong S, Mehta SL, Davis CK, Morris-Blanco KC, Bathula S, Qureshi SS, Vemuganti R (2022) Cerebroprotective role of N6-methyladenosine demethylase FTO (fat mass and obesity-associated protein) after experimental stroke. Stroke 54:245-254.
Morris-Blanco K, Chokkalla AK, Arruri V, Probelsky S, Jeong S, Vemuganti R (2022) Epigenetic mechanisms & potential therapeutic targets in stroke. Journal of Cerebral Blood Flow & Metabolism 42:2000-2016.
Mehta SL, Vemuganti R (2020) Role of circular RNAs in brain development and CNS diseases. Progress in Neurobiology 186:101746.
Kim TH, Mehta S, Lopez M, Sullivan R, Kim H, Morris-Blanco K, Kim H, Kim C, Vemuganti R (2018) microRNA miR- 7a-5p ameliorates ischemic brain damage by targeting α-synuclein. Science Signaling 11(560). Pii: eaat4285.