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Laboratory Head in Neuropathology

F. Hoffmann-La Roche AG
Basel, Canton of Basel-Stadt (CH)
Closing date
Oct 25, 2023

The Position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. 

This position is located in Neurogenomics, a research  section within the Neuroscience and Rare Disease (NRD) therapeutic area, where the primary focus is using genetics and genomics to suggest therapeutic targets, develop a better understanding of disease biology, identify potential biomarkers, and develop therapeutics for some of the most challenging neurological disorders. Our section works closely with other sections and groups within NRD as well as laboratories within our Therapeutic Modalities and Pharmaceutical Sciences groups and Data & Analytics to convert hypotheses into innovative therapeutics for brain disorders across the lifespan.


Job mission

We are offering an outstanding opportunity to recruit and lead a lab whose primary focus will be to understand and quantify neurodegenerative disease pathology in animal models and human post-mortem tissues and biofluids. 

With a deep knowledge and experience in Neuropathology, you will operate at the exciting interface of histopathology and cutting-edge multi-omics. You will have tremendous resources and capabilities, and you will be surrounded by world-class scientists and drug hunters in a state-of-the-art new building located at the pRED center in Basel. 


Your key responsibilities

  • You are recruiting and leading an effective team to understand pathology of neurodegenerative diseases at the cellular level by performing quantitative histopathology, spatial omics, and related experiments.

  • You are bringing deep scientific expertise about the pathology-relevant microenvironment (i.e. how different cell types influence each other) during the neurodegenerative process as a key contributor to multiple projects.

  • You are generating ideas for back translation from clinical trial samples and data to target and/or biomarker identification

  • You are interfacing with omics and in vivo and in vitro models colleagues to design and interpret experiments

  • You are leading drug discovery projects related to neurodegenerative disorders.


Who you are:

  • PhD or MD/PhD in neuroscience or cellular biology with minimum 5 years of experience in Neuropathology 

  • You are a rigorous scientist with a deep understanding and practical experience in cellular neuroscience, including major neural cell type histology in preclinical disease rodent/larger mammal models and post-mortem patient samples 

  • You have expertise in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, ALS, and/or Multiple Sclerosis, including a solid grasp of the literature in neurodegeneration

  • You have experience using multi-omics approaches such as proteomics, transcriptomics, and/or single cell genomics to quantify differences in disease state, with experience integrating two or more of these omics approaches a plus

  • You bring a proven scientific-track record through impactful publications in relevant fields, patents, or substantial contributions to drug development programs

  • You are someone who is driven by the desire to find therapeutics for some of the most complicated and devastating disorders

  • You enjoy teamwork, diligence and efficiency. You are a kind and influential team leader and a trusted and knowledgeable colleague 

  • Working in a multicultural environment motivates you


Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.


Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.


Roche is an Equal Opportunity Employer.

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