Postdoctoral Fellow – Neurobiology of hunger, metabolism and related physiology
Laboratory: Bradford B. Lowell MD, PhD, Professor of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Topic: Neural circuits and synaptic mechanisms underlying control of hunger/satiety, metabolism, neuroendocrine systems, and the gastrointestinal tract.
The Lowell lab seeks to identify the neural mechanisms responsible for the above-mentioned processes. To achieve this, we interrogate the function, regulation and the input/output connectivity of genetically-identified neurons. This is done by combining mice genetically engineered to express DNA recombinases (Cre, Flp, etc.) in transcriptionally-defined neurons with viral vectors or mice that express, in a recombinase-dependent fashion, a panel of “neuroscience tools”. Using these approaches, we then manipulate that neuron’s firing rate to determine its role in regulating behavior and physiology, measure its activity to establish how it responds to discrete sensory, behavioral and physiologic perturbations, and map that neuron’s upstream and downstream synaptic connectivity to uncover its underlying neural “wiring diagram”. Combined, this information is used to construct mechanistic models of how the brain controls physiology and behavior.
Candidates must have PhD, MD, or MD/PhD degrees with research training in neuroscience.
Ideal candidates will have technical expertise in one or more of the following areas: 1) analysis of neural circuitry in mice, 2) manipulation of neural activity, in vivo, using optical and/or chemogenetic approaches, 3) monitoring of neural activity in vivo with Ca2+-based imaging and/or optetrode technologies, 4) brain slice electrophysiology, 5) advanced viral technologies for circuit mapping, manipulation of gene expression and/or for altering neuronal activity, 6) skills related to phenotyping of feeding behavior and/or reward, and/or 7) single neuron transcriptomics.
Current NIH support for the Lowell Lab:
NIH R01 DK075632 Lowell (PI) “The AgRP / POMC -> Paraventricular (PVH) -> Parabrachial (PBN) -> Limbic/Reward Satiety Circuit”
NIH R01 DK089044 Lowell (PI) “Leptin, GABAergic Neurons and Feedback / Feedforward Regulation of Energy Balance”
NIH R01 DK096010 Lowell (PI) “AgRP neurons: circadian control and interactions with the HPA axis”
NIH R01 DK134427 Lowell (PI) “Feedforward Activation of AgRP Neurons and Hunger”
NIH R01 DK122976 Multi-PI R01 Lowell (PI), Liberles (PI) “Leveraging the rich genetic diversity of vagal motor neurons to decode brain-to-gut communication”.
Letters of application and CVs should be emailed to:
Bradford B. Lowell, MD, PhD - email@example.com
Professor of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Harvard Medical School and Beth Israel Deaconess Medical Center are Equal Opportunity/Affirmative Action Employers. Women and minorities are particularly encouraged to apply.