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Postdoctoral Researcher

University of Pittsburgh
University of Pittsburgh, Pittsburgh
Competitive and negotiable
Closing date
Jun 29, 2023

Job Details

Postdoctoral Fellow - To study basal ganglia circuits and plasticity. The Seal laboratory identified a novel form of corticostriatal plasticity that delays for up to 5 months the onset of motor impairments in a mouse model of Parkinson’s disease.  A major goal of the current open Postdoctoral position is to determine the molecular and circuit bases of this novel form of corticostriatal plasticity on motor behavior.  The project currently involves three major experimental paradigms.  1) Analysis direct and indirect pathway spiny projection neurons in the dorsolateral striatum during motor behavior in PD models using Inscopix, in vivo calcium imaging and DeepLabCut in mice.  2) Identification of direct pathway spiny projection neuron plasticity mechanisms using proteomics and viral circuit manipulations in mice.  3) Identification and characterization of brain circuits that modulate arousal and motivation in mice.


Should have a PhD in Neuroscience or related field. Background in brain circuit studies, calcium imaging or proteomic analysis a plus.  


Scientific training of the successful candidate will be enhanced by presenting the work at national and international meetings, obtaining research fellowships, and interacting with other research laboratories at the university and Carnegie Mellon University, particularly those of Drs. Susanne Ahmari, MD Ph.D., Mac Hooks, Ph.D., Matt MacDonald, Ph.D. Eric Yttri, Ph.D. and Aryn Gittis, Ph.D.

The University of Pittsburgh has a vibrant, multidisciplinary, and internationally recognized neuroscience community that includes Neurobiology, Neuroscience, Psychiatry, Pittsburgh Institute for Neurodegenerative Disorders, and the Pittsburgh Center for Pain Research.  The city offers numerous sports, cultural, and gastronomical activities and is affordable for students and young professionals. Consistently, Pittsburgh has been rated Most Livable City in the US by the Economist and Forbes Magazine.

Please submit your cover letter and CV including the names of three references to Dr. Rebecca Seal, Ph.D.



The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EEO/AA/M/F/Vets/Disabled

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