Postdoctoral Associates in Neurodegenerative Diseases: University of Minnesota - Twin Cities
- University of Minnesota
- Minneapolis, Minnesota
- Follows NIH guidelines which includes a competitive benefits package
- Closing date
- Jul 24, 2023
- Graduate School or University
- Job Function
- Postdoctoral Researcher
- Position Type
- Full Time
- Entry Level
Multiple NIH-grant funded openings are available for postdoctoral scientists to study the pathogenic mechanisms of Alzheimer’s disease (AD).
First project aims to define the role of BACH-1 in the AD (RF1AG077396). BACH1 is transcriptional factor that represses Nrf2, a transcriptional factor that induces multiple neuroprotective pathways. We found that pharmacological and genetic repression of BACH1 attenuates AD-related neuropathology and neurodegeneration in transgenic mouse model of AD. We are currently defining how inhibition of BACH1 leads to neuroprotection in AD models.
Second project, working in collaboration with Dr. Michael Farrar (Center for Immunology, UofM), aims to study the role of regulatory T (Treg) cells in AD (R01AG078731). While CNS inflammation, particularly microglial activation, is a key component of AD pathogenesis, peripheral adoptive immunity, largely mediated by T-cells, is emerging as a significant pathologic component in AD. Among the T cells, Tregs functions to attenuate too much inflammatory activation via suppression of effector T-cells and microglia. Initial human studies indicate to reduced Treg function in AD and in mouse models of AD. In this project, we will characterize molecular features of Treg and effector T cells in AD and whether distinct subsets of Tregs can modulate AD pathology in vivo.
The projects will utilize mouse genetics, immunological/cell biological/biochemical approaches, genomic analysis (RNAseq, snRNAseq, Spatial transcriptomics), high-content immunohistochemical analysis, quantitative neuropathology, and behavioral analysis.
The laboratory is funded by multiple grants from Federal/Private sources and involve extensive national/international collaborations with a diverse group of investigators. The laboratory is located within the Wallin Medical Biosciences Building at University of Minnesota, housing the Center for Neurodegenerative Diseases, Institute for Translational Neuroscience, and Center for Immunology. Candidate will join a highly collaborative, vibrant, and supportive laboratory environment currently consisting of multiple postdoctoral fellows, students and supporting staff. Candidates must have a Ph.D. and/or M.D. degree with strong background in relevant Biomedical Sciences. Fluency in English is also essential. We will prioritize individuals who have background or interest in the following approaches: quantitative analysis of neuropathology and neurodegeneration, neuroimmunology, studies of protein quality control, and/or single cell/spatial transcriptomics.
Appointment level and salary will be commensurate with the relevant experience. Candidates should email C.V. (including citizenship/VISA information), brief statement of prior research and future goals (1-2 pages), and contact information for at least 2 referees to Michael K. Lee, Ph.D. (firstname.lastname@example.org).
You will also find this position posted on our UMN careers site: https://hr.myu.umn.edu/jobs/ext/355354
Twin Cities (Minneapolis-St Paul) is 16th largest metro area in USA and considered one of the best cities for young professionals in USA. (https://www.niche.com/places-to-live/minneapolis-hennepin-mn/)
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
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