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Postdoctoral Researcher - Neurosciences

University of California San Diego, Department of Neurosciences - Rissman Lab
UCSD, La Jolla
Salary is commensurate with qualifications and based on published University of California pay scale
Closing date
Apr 12, 2023

Job Details

A position is open for a Postdoctoral Researcher with a strong background in neuroscience to join the research laboratory of Dr. Robert Rissman, Professor of Neurosciences, University of California San Diego (UCSD). Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project will study the role of novel therapeutic strategies and biomarkers for Alzheimer’s disease and related disorders (ADRD). Multiple openings are available and located in San Diego, California.

Supporting postdoctoral, graduate students and other personnel, Dr. Rissman's lab has a center structure with various cores run by senior scientific and technical staff to support/facilitate ongoing and collaborative work.  These cores include administrative/scientific writing, transgenic animal, histopathology, neuropathology, viral vector, in vitro, microscopy and biomarkers.  For more information, please see

Research Description  

The focus of Dr. Rissman’s basic science research is novel biomarker discovery studies in experimental neuropathology, focused primarily on Alzheimer’s disease and related disorders (ADRD). A major focus of his lab in AD biomarkers is studying the utility and mechanistic underpinnings of neuronal exosomes, having published multiple manuscripts demonstrating the ability of exosome cargo to predict cognitive and pathological progression. Dr. Rissman also investigates the contribution of stress and changes in stress signaling intermediates in AD neuropathology. Using transgenic animal models and in vivo pharmacology, experiments focus on preclinical studies to validate new therapeutic strategies against neuronal loss, beta-amyloid deposition, tau phosphorylation, behavioral, and synaptic changes. Complimenting this work, Dr. Rissman also employs comparative approaches using postmortem human tissues to validate transgenic mouse and in vitro studies.

Research Activity

  • Molecular biology and biochemical methods 
  • Immunohistochemistry and microscopy studies on brain and other tissues.
  • Behavioral assays and motivated behavior
  • Work with genetically modified mice
  • Live-cell imaging of neuronal/immune cell physiology
  • Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues
  • Perform pharmacological manipulations in vivo
  • Prepare and write manuscripts for publication

Applicants should hold (or soon receive) a Ph.D. in Neuroscience or a related discipline. Experience with rodent behavioral testing is preferred but not required. Successful applicants should be highly self-motivated, have outstanding experimental skills and be able to think independently but also work well in a team. One first author publication from previous research work is required to be eligible. 

Document Requirements 

  • Curriculum Vitae – Your most recently updated CV or biosketch
  • Cover Letter 
  • 2-4 letters of reference 
  • 1 first author publication


UCSD’s Department of Neurosciences has a rich, internationally acclaimed history for its contribution to the research of neurodegenerative diseases, particularly AD. Research studies of AD and other neurodegenerative disorders at UC San Diego are part of the clinical bench strength of the UC System. For the past 30 years, UC San Diego has been a leader in AD research and home to the prestigious Shiley-Marcos Alzheimer’s Disease Research Center (ADRC).

Dr. Robert Rissman is Professor of Neurosciences at the University of California San Diego (UCSD). He conducts research in his laboratory on the UCSD School of Medicine campus in La Jolla, CA. Dr. Rissman is also the Director of Neuropathology and Biomarker Cores of the Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) at UCSD, a founding Director of the Alzheimer’s Disease Cooperative Study (ADCS) Biomarker Core, and has a joint appointment as a Research Biologist at Veteran’s Administration Healthcare San Diego. 

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All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.


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