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Postdoctoral Research Fellows – Selective Autophagy in Aging and Neurodegeneration

Mayo Clinic in Jacksonville, Florida
Jacksonville, Florida
Closing date
Dec 27, 2022

Postdoctoral research positions are available in the laboratory of Dr. Wolfdieter Springer to investigate pathogenic mechanisms of neurodegeneration at Mayo Clinic in Jacksonville, Florida. The Springer lab focusses on selective autophagy pathways, in particular mitophagy, and how alterations therein contribute to aging and neurodegenerative disorders. The lab employs a multi-disciplinary approach using state-of-the-art techniques in cell biology, biochemistry, and imaging to illuminate the underlying disease biology in iPSC-derived cell and organoid models, in vivo in mice, and in human clinical and neuropathological specimens.

Specific research projects include 1) investigation of selective autophagy mechanisms in Alzheimer’s disease, Lewy body dementia, and Parkinson’s disease, 2) biomarker development to monitor selective autophagy pathways in cells, tissues, and biofluids, 3) validation of disease signatures resulting from altered mitophagy, as well as 4) genetic and pharmacological stimulation of mitophagy during aging and neurodegeneration.

Requirements: Applications are invited from highly motivated candidates holding a recent Ph.D. or M.D./Ph.D. with a strong research background in neuroscience, cell biology, or biochemistry. Expertise in iPSC models, mouse work, or multi-omics approaches is desirable. In addition, qualified candidates should have a record of impactful, peer-reviewed publications. Excellent verbal and written communication skills in English are essential.

How to Apply: Qualified candidates should send a cover letter outlining research interests and achievements along with their curriculum vitae to Wolfdieter Springer (

Mayo Clinic and the Department of Neuroscience offer an outstanding research and training environment with a competitive stipend and a generous fringe benefit package.

Why Mayo Clinic: The Research shield at Mayo Clinic is committed to creating a diverse environment and recognizes that diverse research teams make better decisions, are more equipped to solve complex problems and adapt to change, and produce better outcomes. That diversity is about opening up to unconventional ideas that create better outcomes, while recognizing colleagues' unique contributions. Become part of the legacy that embraces these differences and enables us to provide the best care to patients from all over the world. 

Site description: Jacksonville is the largest city in area in the continental United States. A beautiful coastal Florida city that features excellent year-round climate, over 20 miles of beaches and outstanding outdoor recreational, cultural and family-oriented amenities. The “River City by the Sea” has an excellent school system, reasonable cost of living and a thriving business environment. Medical professionals and patients are drawn to Jacksonville by an extraordinary network of high-profile healthcare facilities. Jacksonville continues to grow as more people relocate from all over the U.S. and abroad, to see what the great River City has to offer!


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