Postdoctoral Position (Electrophysiology) to Study KCNMA1 Channelopathy

Research in the Meredith Lab focuses on ion channel regulation of information coding in brain and muscles.  We combine the genetically-encoded functional channel alterations with ex vivo and in vivo electrophysiology and physiology. Two recent goals of our studies are to identify the fundamental biophysical properties of BK channels that cause neurological disease (KCNMA1 channelopathy) and that underlie circadian time in the brain’s central clock.  Techniques in the lab center around multi-level electrophysiological recordings:  voltage- and current-clamp, multi-electrode array, and EEG/EMG/ECG telemetry, using heterologous cells, neurons, acute and organotypic brain slices, to awake, behaving animals.

For this NIH-funded postdoctoral position, we are seeking a highly motivated team-player to contribute to our studies of a new neuromuscular channelopathy defined by mutations in KCNMA1, the gene encoding the large conductance Ca²⁺-activated BK channel.  The project involves investigating changes in excitability in patient-derived cells and transgenic mouse brain slices.  See our recent publications at meredithlab.org.

To apply:  Candidates should have a PhD in biophysics, neuroscience, physiology, or other relevant field.  Experience with electrophysiological recordings is required.  Excellent oral and written communication skills should be demonstrated through publications and research presentations.  Individuals from underrepresented groups in the sciences are especially encouraged to apply.

Please send by email to Dr. Andrea Meredith (ameredith@som.umaryland.edu) with:

     - your CV

     - a letter describing your research accomplishments, expertise, and career goals

     - contact information for three references

The Department of Physiology offers outstanding research and NIH-funded postdoctoral training opportunities.  Our faculty have made fundamental discoveries in ion channel biophysics in cardiac, neuronal, and renal physiology.  Departmental postdocs benefit from formal career development resources through the Office of Postdoctoral Scholars, including grant writing and other professional activities.

The University of Maryland School of Medicine is the oldest public medical school in the U.S. and the founding campus of the University of Maryland system.  The SOM ranks 6th among all 76 public medical schools.  Located in downtown Baltimore, our campus is adjacent to Oriole Park and Raven’s Stadium, and within walking distance of excellent dining, shopping, and entertainment at Baltimore's Inner Harbor. The West Side Cultural District surrounds the University with residential, retail, and performing arts venues. The University is ~60 minutes from NIH (Bethesda, MD), 38 miles from the National Mall (Washington, DC), and is also close to Philadelphia and New York City.