Post-doctoral fellow position available in the Institute for Brain Disorders and Neural Regeneration of the Albert Einstein College of Medicine and the Laboratory of Stem Cell Biology and Epigenomic and Regenerative Medicine of Dr. Mark F. Mehler. Our laboratory group has a special interest in the developmental pathogenesis of neurodegenerative diseases, with a focus on Huntington's disease, and the novel early molecular, cellular, and systems-level impairments that predispose to degenerative dementia during later life with a focus on cutting edge therapeutic initiatives to identify previously unanticipated epigenetic and regenerative target processes that may be more efficacious when employed during the pre-manifest stage of disease.
We utilize innovative conditional mouse disease models, selective transplantation protocols targeting developmental critical periods for neural network organization and plasticity, human neuropathological materials, and advanced neural organoid models to interrogate a new disease model. This model postulates that the characteristic molecular architecture of the disease gene trinucleotide expansion repeats in concert with the presence of a series of genetic modifiers, including DNA damage response single nucleotide polymorphisms, collaborate to selectively impair the specification and maturation of a specific neuronal subtype uniquely involved in sculpting cortico-striatal connectivity and plasticity, and that deregulation of these interrelated maturational processes determines the precise age of disease onset and disease course.
The position will involve tissue processing, immunofluorescence microscopy and ultrastructural analysis, stereological examination, ex vivo high-resolution neuroimaging techniques, sequential neurobehavioral testing procedures, allograft preparation for transplantation analyses, optogenetic protocols, molecular techniques including single cell RNA-seq, histone occupancy, ChIP-seq, spatial transcriptomics, examination for the molecular architecture of trinucleotide repeat expansion and SNPs of targeted DNA repair genes, and protocols for generation of patient-specific IPSCs and use of advanced neural organoid technologies and interrogation of their disease evolution. Special consideration will be given to applicants with a strong training background in this interdisciplinary topic area and who are highly motivated to contribute new perspectives, analytical tools and scientific advances through research and review publications, biomedical meeting presentations and collaborative initiatives.
The position provides salary and full fringe benefits and the possibility of post-doctoral housing facilities at our school. Applicants should have a PhD, MD of MD-PhD degree and relevant research experience is preferable.
Please submit CV, statement of interests and career goals, and contact information for 3 referees who can provide reference letters. These can be forwarded to:
Mark F. Mehler, MD, FAAN, FANA,
Alpern Professor and University Chair,
The Saul R. Korey Department of Neurology,
Director, Institute for Brain Disorders and Neural Regeneration,
Director, Laboratory of Stem Cell Biology and Epigenomic and Regenerative Medicine,
Albert Einstein College of Medicine,
1410 Pelham Parkway South,
Kennedy Center 401,
Bronx, New York 10461, USA,
The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.
Apply Here: https://www.click2apply.net/BzoA7mUANzal1FManF1rQ4