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Research Scientist - Stem Cell-Based Disease Modeling and Gene Editing

The Collaborative Center for X-Linked Dystonia-Parkinsonism
Boston, Massachusetts
Closing date
Oct 2, 2022

The Collaborative Center for X-Linked Dystonia-Parkinsonism (CCXDP) is a global disease consortium based at Massachusetts General Hospital that is focused exclusively on a rare neurodegenerative disorder endemic to the Philippines. We are an international coalition of scientists, physicians, and industry partners throughout North America, Europe, and Asia all working together to solve X-Linked Dystonia-Parkinsonism (XDP), a severe movement disorder. The hub of our network is a group of core investigators at MGH with affiliations spanning Harvard Medical School, the Harvard Stem Cell Institute, and the Broad Institute.

CCXDP is seeking a Research Scientist to lead a broad range of studies applying genome editing technologies to interrogate DNA sequence variants linked to XDP and related movement disorders in induced pluripotent stem cell (iPSC) models. You will work closely with a dynamic team including senior investigators, junior faculty members, PhD-level staff scientists, research technicians, and students, while contributing to large collaborative projects involving CCXDP-supported laboratories around the world.

We are looking for neuroscientists who share our passion for solving rare disorders of the brain with specific experience in iPSC disease modeling and genome editing.  Prior experience differentiating engineered iPSC lines towards neuronal and glial lineages is strongly preferred.  This individual will also be responsible for characterizing cellular phenotypes in edited iPSCs using diverse molecular, biochemical, and imaging-based assays.

Successful applicants should have strong communication skills and the ability to work effectively in dynamic project teams.

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