A postdoctoral research fellow position is available in the laboratory of David C. Martinelli at the University of Connecticut School of Medicine, Department of Neuroscience. https://health.uconn.edu/synapse/
The Martinelli lab uses numerous experimental techniques to study synaptic adhesion proteins, which lie at the junction of our genes and our behavior and are critical for initiating and stabilizing synaptic changes in a multitude of ways. Our goal is to understand the molecular logic of how synaptic adhesion proteins, in a defined brain circuit, orchestrate synaptic formation, modification, and function, and to ultimately provide an explanation for how these events influence behaviors, in particular the aberrant behaviors associated with neuropsychiatric diseases.
The immediate focus of research is on the neuronally secreted C1q-like family of proteins. Our lab studies the biochemical interactions with their pre- and post-synaptic protein binding partners, their synaptic signaling activities, and their eventual behavioral consequences. A priori, their localization in the synaptic cleft almost predestines them to have neuropsychiatric disease relevance. How C1q-like proteins and their binding partners influence synapses and ultimately behaviors is unknown. The techniques used in the lab to answer these questions encompass biochemistry, genetics, cell biology, circuit analysis using viral vectors, and mouse behavioral assays.
Additionally, the laboratory has branched into glial biology, and has received a grant to research new molecular targets to treat the disease of multiple sclerosis, a debilitating disease of neuron demyelination and neurodegeneration.
We are looking for a collegial researcher who is passionate about science and is transitioning from graduate school. Applicants should have training in neuroscience and a PhD and/or MD (or will receive degree soon). Experience with mouse research is preferred. The candidate must be capable of working both collaboratively and independently, and collecting, analyzing and preparing research data for publication. Excellent English communication skills are required.
Position is available immediately and applications will be considered on an ongoing basis until filled.
Interested applicants should email to firstname.lastname@example.org a single file that includes a cover letter (describing research experience, career goals, and interest in the position), CV, and the contact information for at least 3 individuals willing to provide a letter of recommendation if asked. Please indicate that this is postdoc applicant information in the subject line and mention this advertisement.