A postdoctoral fellow position is open in the Nuber laboratory at Brigham and Women's Hospital and Harvard Medical School. The candidate is curious to study a-synuclein biology in mice and cell culture models of Parkinson's disease (PD). The research focuses on mutations that cause Parkinson's and impact of lipid changes in the disease mechanisms. The new project uses novel mutant mice (GBA1 or alpha-synuclein) to study early-onset synucleinopathy. In addition, new mice will be generated to analyze tetramer abrogation by other familial PD a-synuclein mutations. Readouts include therapeutical approaches, behavioral testing as well as lipid-profiling, biochemical and histopathological analyses.
- A Ph.D. in neuroscience or biochemistry or a related biological field.
- Excellent track record of publications.
- Direct experience with mice in wet lab work: protein and histological analyses is essential
- Cell culture (primary neurons and/or induced human neurons) experience preferred, listed in detail in the CV.
- Self-motivated and driven individual able to work both independently and in a team.
- Excellent oral and written communication skills in English.
- we hope for a consistency for ~ 2-3 years.