Postdoctoral Associate

Weill Cornell Medicine
New York City, New York
based on NIH guidelines
Closing date
Aug 29, 2022

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Job Details

The Hemmings/Platholi lab in the Department of Anesthesiology at Weill Cornell Medicine is seeking two accomplished and motivated Postdoctoral Associates to join our neuropharmacology/neuroscience team in investigating the molecular, cellular, and functional mechanisms of anesthetic action.
Project one is to identify the functional consequences of anesthetic effects on synaptic transmission and plasticity. This research will explore transmitter-specific effects of general anesthetics at hippocampal synapses using molecular probes and optogenetic biosensors of exocytosis, Ca2+ dynamics and voltage. Changes in neural ensemble activity associated with these molecular mechanisms will be observed in vivo using fiber photometry. Opportunities also exist for experience in the electrophysiology and molecular biology of sodium channels.
Project two is to identify changes in ion channel expression and function that coincide with hyperexcitability in early neurodegeneration and the role of general anesthetics as novel inhibitors of neuronal excitability in neurodegeneration. Research strategies will explore the function of sodium channels in early Alzheimer’s Disease using molecular biological techniques combined with in vivo Ca2+ imaging by fiber photometry and behavioral studies in transgenic mouse models.


The Hemmings/Platholi lab in the Department of Anesthesiology at Weill Cornell Medicine is interested in the effects of general anesthetics on neurotransmitter release and on their interactions between specific pre- and post-synaptic proteins involved in the control of synaptic transmission and plasticity. We study these effects at the molecular, cellular, functional, and behavioral levels in isolated nerve terminals, brain slices, cultured cells and neurons, and animal models using molecular probes and optogenetic biosensors. Techniques include fluorescence imaging of exocytosis and Ca2+ dynamics, time-lapse imaging of dendritic spines, in-vivo neural ensemble activity using fiber photometry, and electro-physiological approaches.
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