Neurovirology of Alzheimer’s disease

• Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT. Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus. Neuron 2018; 99: 64-82. doi: 10.1016/j.neuron.2018.05.023.

• Readhead B, Haure-Mirande JV, Mastroeni D, Audrain M, Fanutza T, Kim SH, Blitzer RD, Gandy S, Dudley JT, Ehrlich ME. miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease. Acta Neuropathol 2020; 140: 295-315. doi: 10.1007/s00401-020-02185-z.

Molecular cell biology and pharmacology of viral pathogenesis

• Barbet G, N-Gupta P, ..., Tortorella D, Tampé R, Khanna K, García-Sastre A, Blander JM. TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nature Immunology 2021; 22: 497-509. doi: 10.1038/s41590-021-00903-7.

• Stein KR, Gardner T, Hernandez R, Kraus T, Duty J, Ubarretxena-Belandia I, Moran T, Tortorella D. CD46 facilitates entry and dissemination of human cytomegalovirus. Nature Commun. 2019; 10 :2699. doi: 10.1038/s41467-019-10587-1.

• Duty JA, Kraus T, …Krammer F, Bresson D, García- Sastre A, Fu Y, Lee B, Powers C, Moran T, Ji H, 
  Tortorella D, Allen R.  Discovery of a SARS-CoV2 Broadly Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants bioRxiv 2022.01.19.476998; doi.org/10.1101/2022.01.19.476998.

Prerequisites for Postdoctoral Fellows and Research Scientists

• PhD in virology, cell biology, immunology, biochemistry, molecular biology, pathology, or related discipline.
• Evidence for independent skills in virology, molecular biology, and standard immunoprotein methods (e.g., immunoblotting, immunoprecipitation, immunohistochemistry) required.

Inquiries and applications should be sent to  domenico.tortorella@mssm.edu