The Venkatesh Lab is seeking a highly motivated scientist to join our pioneering research efforts in the emerging field of cancer neuroscience. Our lab’s exciting new area of research lies at the intersection of cancer biology and neuroscience – we focus on characterizing and therapeutically targeting electrical components of disease pathophysiologies. By improving our understanding of the cellular and molecular mechanisms involved in neuron-glioma communication and circuit formation in and outside of the brain, the Venkatesh Lab aims to harness the systems level microenvironmental dependencies of tumor growth to develop innovative therapeutic treatments.
We are looking for a Research Scientist with a background in electrophysiology and advanced microscopy, strong organizational skills, and the ability to attain a high degree of independence in a new and dynamic research environment. In this role, the individual will conduct a variety of experiments including in slice and in vivo neuroimaging, stereotactic surgeries, and electrophysiology. As one of the first members of the Venkatesh lab team, the candidate will also contribute to research work and publications on novel neuron-glioma circuit interactions using advanced neuroscience techniques.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Implement and develop in vitro electrophysiological protocols and assays to support multiple projects.
- Execute in slice and ex vivo electrophysiology/optical recordings. Microscopy imaging including confocal and 2-photon calcium imaging
- Performs stereotactic mouse survival surgeries for multiple projects/collaborations.
- Publish scholarly reports and present at scientific conferences.
MS in a biological/physical science required, PhD Preferred. Ideally 3-5 years of previous experience in a research environment.
- Experience with in vitro and ex-vivo patch clamp (cell lines, primary neurons, or slice electrophysiology).
- A strong understanding of microscopy (including brightfield, confocal and 2-photon), digital-imaging platforms, image quantification and interpretation is essential.
- Experience with other neuronal/glial function assays desirable. (eg. Ca2+ imaging, MEA)
- Expertise working with acute brain slice preparations and, ideally, primary neuronal cultures.