The Neural Connectivity Development in Physiology and Disease laboratory at the Burke-Cornell Neurological Institute, led by Yutaka Yoshida, PhD, is currently seeking postdoctral fellows with laboratory experience in either molecular biology or neuroscience. The Yoshida laboratory is interested in formation, function, and regeneration of motor circuits controlling locomotor and skilled movements. We especially study descending motor circuits including corticospinal circuits using various techniques such as molecular biology, mouse genetics, trans-synaptic viruses, optogenetic and chemogenetic tools, and spinal cord injury.
Recent representative publications from the Yoshida lab:
1. Yoshida Y., Isa T. (2018). Neural and genetic basis of dexterous hand movements. Curr Opin Neurobiol. 52, 25-32.
2. Ueno M., Ueno-Nakamura, Y., Li J, Gu Z., Niehaus J., Maezawa M., Crone S.A., Goulding M., Baccei M.L., and Yoshida Y. (2018). Corticospinal circuits from the sensory and motor cortex differentially regulate skilled movements through distinct interneurons. Cell Reports, 23, 1286-1300
3. Gu Z., Sarrad N., Ueno M., Liang M., Li J., Enquist L.W., Baccei M.R., Martin J.H., and Yoshida Y. (2017). Skilled movements require non-apoptotic Bax/Bak pathway-mediated corticospinal circuit reorganization. Neuron, 94, 626-641.
4. Gu Z., Kalamboglas J., Yoshioka S., Han W., Zhuo L., Imamura Kawasawa Y., Pochareddy S., LiZ., Liu F., Xu X., Wijeratne S., Ueno M., Blatz E., Salomone J., Kumanogoh A., Rasin M.R., Gebelein B., Weirauch M.T., Sestan N., Martin J.H., and Yoshida Y. (2017). Control of species-dependent cortico-motoneuronal connections underlying manual dexterity, Science, 357, 400-404.
5. Imai F., Chen X., Weirauch M.T., and Yoshida Y. (2016). Requirement of Dicer in maintenance of monosynaptic sensory-motor circuits in the spinal cord. Cell Reports, 17, 2163-72.
6. Ueno M., Ueno-Nakamura Y., Niehaus J., Popovich P.G., and Yoshida Y. (2016). Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nature Neuroscience, 19, 784-787.
7. Imai F., Adam M., Potter S., and Yoshida Y. (2021). HoxD transcription factors define monosynaptic specificity sensory-motor connections in the developing spinal cord. Development, 148 (12): dev191122.
8. Nakamura Y., Ueno M., Niehaus J., Lang R., Zheng Y., and Yoshida Y. (2021). Modulation of both intrinsic and extrinsic factors synergistically promotes rewiring of corticospinal circuits after spinal cord injury. Journal of Neuroscience, 41 (50): 10247-10260.
The Burke Neurological Institute is an equal opportunity employer with competitive pay scales and benefits.
To apply, candidates should email their resume with cover letter to Dr. Yutaka Yoshida, Ph.D. at firstname.lastname@example.org. In the subject line, please include your name followed by “Postdoctral Fellow Applicant.”
PhD with experience in either molecular biology or neuroscience