Post Doctoral

Employer
Brigham & Women's Hospital- Neurology
Location
Boston, Massachusetts
Salary
3
Closing date
Feb 12, 2022
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The research focuses on determining whether lipid-dependent changes that affect the a-synuclein homeostasis and lead to Parkinson’s pathology can be rescued in brain neurons.

The PI’s previous work demonstrated that upstream abrogation of physiological a-synuclein tetramers, induces a progressive, L-DOPA-responsive motor syndrome and cortical and dopaminergic fiber loss in familial PD E46K (“1K”) and “3K” mutant mice. The new project uses these unique mouse models to study early-onset synucleinopathy. In addition, new models will be generated to analyze tetramer abrogation by other familial PD a-synuclein mutations. Readouts include behavioral testing as well as biochemical and histopathological analyses and lipid profiling.

Candidates with a PhD within 1-3 years are preferred, with strong experience in rodent modeling.  Prior work with primary neurons and/or induced human neurons is welcome. Only candidates with demonstrated expertise and publications in this field should apply.

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