The laboratory of Martin Hruska, Ph.D., in the Department of Neuroscience at West Virginia University and the Rockefeller Neuroscience Institute is seeking a highly motivated and creative post-doctoral researcher for the NIH-funded position related to structural and molecular mechanisms of synaptic remodeling during neurodegeneration and following an injury such as stroke. While the successful candidate's interest will be matched with the laboratory interests, we are particularly looking to fill the NIH-funded position to investigate the synaptic mechanisms of functional recovery after stroke.
The efforts of the Hruska lab focus on defining how the molecular nanoarchitecture of synapses changes during normal brain function (structural plasticity) and how these processes are impacted by diseases of the brain (stroke, AD). To achieve these goals, we use state-of-the-art stimulated-emission depletion (STED) super-resolution microscopy of individual dendritic spine synapses. In addition to imaging fixed preparations (brain sections, cultured cells), we also use STED in living neurons to define how synaptic nanoarchitecture is dynamically modified after the induction of structural plasticity. We are currently developing new reagents and techniques to image thin brain sections in mouse disease models to determine how neurological disorders impact the nanoarchitecture of synapses.
We seek highly self-motivated and creative post-doctoral researchers, particularly those who recently acquired Ph.D. or equivalent degrees. Candidates with prior expertise in animal models of disease (hypoxia-ischemia, AD models) are encouraged to apply. Expertise in confocal and super-resolution imaging is advantageous since the Hruska lab has the new Leica Stellaris 8 STED system. Thus, we are set up for super-resolution imaging of synapses in vitro and in vivo. Please go to https://medicine.hsc.wvu.edu/neuroscience/faculty-labs/martin-hruska-phd/ for the lab details. We are a highly collaborative department, and ample opportunities exist for interactions with various faculty investigating the function and dysfunction of synapses at systems and molecular levels. The lab prioritizes mentorship and cutting-edge science. As a result, post-doctoral fellows will get a chance to present their work locally, nationally, and internationally.
At WVU, we strongly believe in work-life balance and keeping time for things we love outside our work. WVU Research Corporation offers a comprehensive benefits package with a variety of options to suit your needs. Please click here to learn more about these benefits and to apply. Interested applicants should also directly email updated CV, statement of research interest and past research experience, and contact information for three references to firstname.lastname@example.org.
Hruska lab is also recruiting a research technician through the WVU HR (https://wvu.taleo.net/careersection/staff/jobdetail.ftl?job=18365). The selected researcher will participate in the design and implementation of laboratory studies and be responsible for the organization and data management. Previous experience in cell culture, rodent handling, molecular techniques (PCR, western blot), immunohistochemistry, and confocal imaging are a plus.