The Regeneron Genetics Center (RGC) is seeking a scientist with strong command of molecular biology, biochemistry, molecular genetics, in vitro and in vivo disease modeling to support target discovery and validation based on our human genetic findings in neurological and associated disorders. You should have multidisciplinary expertise, with a special emphasis in the areas of molecular and cellular neuroscience, neurodegeneration, neuroinflammation and/or neuro-ophthalmology, and in vivo mouse modeling. Prior experience with human iPS cells and/or organoids would be welcome. The candidate will collaborate closely within the RGC-Biology group and other RGC teams as well as across the organization to coordinate activities and collaborations. Candidates who aspire to become part of an innovative and scientifically inspiring environment, with innovative facilities and technologies, who enjoy collaborating within and outside of a team, have a passion for scientific discovery, face challenges with a positive attitude, can multitask and work independently in a fast-paced environment, and are dedicated to high quality research, are encouraged to apply.
A typical day would include:
- Use experimental approaches in human and mouse cell-based systems, including human iPSCs, human iPSC-derived neurons and microglia, and mouse primary neuronal cultures, for molecular, cellular and functional characterization of new genetic variants associated with neurodegenerative and mental disorders, cognitive aging, neurodevelopmental and eye diseases.
- Design, plan, and independently perform in vivo experiments using mouse models to unravel molecular, cellular and behavioral phenotypes associated with human genetic findings associated with neurological disorders.
- Use reporters, cell lines and mice, biochemistry and/or imaging for characterization of disease-related mechanisms, including proteasome and autophagy, lysosomal function and cellular homeostasis.
- Perform biochemical and/or imaging-based experiments to examine neuronal function, neuronal connectivity, microglia responses and neuroinflammation in vitro and in vivo.
- Explore novel technologies and recommend and develop new models (in vitro and in vivo) and methods for improving the breadth, translational relevance, and efficiency of experiments.
- Design and conduct experiments and provide advanced data analysis under minimal supervision.
- Keep up-to-date and well-organized records of experiments and generate experimental reports.
- Analyze data across experiments and projects, formulate therapeutic hypotheses and communicate findings and ideas via presentations in RGC and in senior management meetings.
- Collaborate with cross-functional teams across the company to support the drug development pipeline.
This role may be for you if you are:
- An independent problem solver able to excel in a fast-track environment while leading and coordinating multiple projects in a highly collaborative fashion.
- A strong communicator and presenter who is highly organized.
- Hard-working and enjoy the matrix environments and multidisciplinary teams, team-oriented
To be considered for this role you must possess a PhD in Neuroscience or related field with a minimum of 3 years of relevant postdoctoral training including independently leading own projects. Excellent publication record. Ability to work both independently and in a team. Managerial experience preferred, which can include overseeing junior staff. Solid understanding of mechanisms of neuronal function and neuronal communication. Background in neuroinflammation will be a plus. Strong hands-on experience in molecular, biochemical and cellular biology methods. Hands-on experience with primary neuronal cultures and/or human iPSC-derived neurons highly preferred. Experience using mouse models of neurological diseases highly preferred. Experience with behavioral phenotyping of mice, desirable.