Postdoctoral Fellow

Employer
University of Washington
Location
Seattle, Washington
Salary
$60,000 to $70,000 plus health care coverage and retirement plan
Closing date
Nov 8, 2021

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Job Details

Postdoctoral Research Position Available

Calcium Channel Regulation, Neuroplasticity, Spatial Learning, and Memory

William A. Catterall, Department of Pharmacology and Neuroscience Program

University of Washington, Seattle, WA 98195-7280 USA

Calcium influx through voltage-gated calcium channels in presynaptic nerve terminals initiates synaptic transmission. Regulation of these presynaptic calcium channels modulates synaptic plasticity, spatial learning, and memory. Cav2.1 channels that conduct P/Q-type calcium currents  in nerve terminals form a large signaling complex, which includes SNARE proteins, protein kinases and phosphatases, calmodulin, and calmodulin-like neural calcium sensor proteins. We study the regulation of Cav2.1 channels by this presynaptic signaling complex in transfected cells and cultured neurons in vitro and in mutant mouse lines with specific mutations that alter calcium channel regulation in vivo. The functional impacts of mutations that alter calcium channel regulation are determined by in vitro electrophysiological studies of dissociated neurons and brain slices and by in vivo electrophysiology, including measurements of sharp-wave ripples, place cell formation, and other functional read-outs of neuronal circuits. In addition, the behavioral impacts of calcium channel mutations are determined by analysis of spatial learning and memory, including the Barnes Maze, context-dependent fear conditioning, and social interaction. The overall goal of these studies is to understand how calcium channel regulation of synaptic transmission controls learning and memory at the molecular, cellular, circuit and behavioral levels. 

We seek enthusiastic well-trained neuroscientists who are excited about the opportunity to analyze the role of calcium channel regulation in spatial learning and memory from molecules to the brain. 

Salary: $60,000 to $70,000 depending on experience. 

University of Washington fringe benefits, including health care coverage and a retirement plan. 

Position Requirements: 

PhD or equivalent in neuroscience, physiology, pharmacology, or a related discipline.

Experience in molecular biology, cell biology, and electrophysiology using patch clamp and brain slices is required. Experience in mouse genetics and behavior is valuable. 

References:

Djillani D, Bazinet J, Catterall WA (2021) Synaptotagmin-7 potentiates facilitation of Cav2.1 channels. Soc. Neurosci Abst.

Nanou E, Catterall WA. (2018) Calcium channels, synaptic plasticity, and neuropsychiatric disease. Neuron 98:466-481. 

Nanou E, Lee A, Catterall WA. (2018) Control of excitation/inhibition balance in a hippocampal circuit by calcium sensor protein regulation of presynaptic calcium channels. J Neurosci. 38:4430-4440. 

Nanou E, Scheuer T, Catterall WA. (2016) Calcium sensor regulation of the Cav2.1 channel contributes to long-term potentiation and spatial learning. PNAS 113:13209-13214.

Nanou E, Sullivan JM, Scheuer T, Catterall WA. (2016) Calcium sensor regulation of the Cav2.1 channel contributes to short-term synaptic plasticity in hippocampal neurons. PNAS 113:1062-1067. 

Nanou E, Yan J, Whitehead NP, Kim MJ, Froehner SC, Scheuer T, Catterall WA. (2016) Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic Cav2.1 channels. PNAS 113:1068-73. 

University of Washington is an affirmative action, equal opportunity employer. All qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.

 

Company

The University of Washington is a major biomedical research institution in Seattle, WA. It has leading research and teaching programs in all aspects of neuroscience.
Find Us
Telephone
2066163343
Location
1959 NE Pacific St.
Seattle
WA
98195
US

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