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Postdoctoral Research Scientist - Modeling genetic epilepsies to advance precision medicine

University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Negotiable based on experience
Closing date
Oct 30, 2021
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The Heinzen laboratory in the Division of Pharmacotherapy and Experimental Therapeutics, in collaboration with the Eshelman Institute for Innovation, in the Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill is looking to immediately fill multiple postdoctoral fellowship positions to study novel molecular mechanisms across multiple types of genetic epilepsies to identify convergent disease mechanisms and novel drug targets. 

The successful candidates will be part of a highly interdisciplinary environment to develop induced pluripotent stem cell derived neuronal models of genetic epilepsies and apply cutting-edge technologies including electrophysiology, single-cell RNAseq, chromatin conformation capture technique, optogenetics, genetic encoded biosensors of neurotransmission, and live cell imaging, to study cellular and molecular signatures associated genetic epilepsies.  Well-defined cellular and molecular signatures will be fed into the drug discovery pipeline and/or subjected to CRISPR-screens to identify druggable genetic modifiers as part of the Drug Discovery Initiative led by the Eshelman Institute of Innovation.  

The ultimate goal is for postdoctoral fellows to develop specialized skill sets to drive independent research programs that can launch independent research careers. 

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