A Postdoctoral Associate position is available in the laboratory of Dr. Bryen A. Jordan in the Department of Neuroscience at Albert Einstein College of Medicine in New York. The position is available immediately with salary compensation following NIH standards.
We recently identified patients around the world harboring monogenic deletions of the ANKS1B gene. Our findings corroborate previous genome-wide and genetic studies implicating ANKS1B in brain disorders and formalize a link between ANKS1B haploinsufficiency and a previously uncharacterized neurodevelopmental disorder. ANKS1B encodes for AIDA-1, a brain-specific protein enriched at neuronal synapses that regulates NMDAR function and synaptic plasticity. We recently found that AIDA-1 is also expressed in oligodendrocytes at neuron-OPC synaptic junctions. Our research suggests that a synaptopathy of neuron-OPC synapses underlies disease pathophysiology. The long-term goal of our research is to define the mechanisms underlying AnkSyd and to identify therapeutic targets. Using animal and cellular models of disease, we hope to elucidate the mechanisms underlying an uncharacterized brain disorder and are looking for a talented scientist to join our team.
A doctoral degree in the research field of neuroscience, biochemistry, or cell biology would be ideal. Excellent scientific writing and oral communication skills are required. Experience with oligodendrocytes, iPSCs, and organoid cell cultures, as well as with animal models of disease would be preferable. Interested candidates please forward your curriculum vitae and names of three references to Dr. Bryen A. Jordan.