Postdoctoral Fellow in Wainger Lab at Massachusetts General Hospital/ Harvard Medical School

Employer
Massachusetts General Hospital
Location
Boston, Massachusetts
Salary
NIH level based on experience or above
Closing date
Nov 8, 2021
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We are looking for a highly motivated, creative, well-trained, meticulous, and ambitious postdoctoral fellow to lead studies on pain in the laboratory of Brian Wainger, MD, PhD at Massachusetts General Hospital and Harvard Medical School. Our lab is dedicated to developing therapies for treating sensory and motor neuron diseases, in particular pain and amyotrophic lateral sclerosis. We use a complementary set of tools including high-content imaging, patch and multi-electrode array recording, calcium imaging, iPSC modeling, gene editing, bulk and single-cell RNA sequencing, and analysis of human tissue and samples from the MGH clinics and national repositories.

We have recently developed a high-content calcium imaging platform that provides single-cell response resolution, liquid handling to apply multiple longitudinal stimuli, and automated data analysis. We have used this for several novel applications, including unbiased identification of inflammatory pain mediators and screening for blockers of nociceptor activation. We believe that this novel technique offers exciting possibilities for understanding pain mechanisms and developing new pain treatments. It would best be applied in combination with traditional patch clamp electrophysiology, in vivo pain models, and genomic analyses. We also will be expanding a pain gene therapy program in our group.

More information can be found at: waingerlab.org

The candidate should have a doctoral degree, strong research background, and initiative to lead projects. The ideal candidate would have experience in physiology (patch clamp and calcium imaging), pain animal models, programming in R and statistical knowledge sufficient for handling datasets and addressing different variance components for large scale experiments (phenotypic screens). Also relevant would be experience in stem cell biology and bioinformatic analyses.

Our lab is active within Massachusetts General Hospital, the Broad Institute, Harvard Program in Neuroscience, and Harvard Stem Cell Institute. We also have several leading academic and industry collaborations. The candidate will be closely involved in and present at all these forums. The position is for at least two years and is fully funded. Postdoctoral fellows are supported by skilled research assistants.

Please send cover letter, letters of reference, statement of research experience and career goals, and CV to Brian Wainger (brian.wainger@mgh.harvard.edu).

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