Postdoctoral Researcher (Glia-Neuron interaction)

Location
Boston, Massachusetts
Salary
Salary is based on NIH standard with consideration of years of experience
Posted
Aug 10, 2021
Closes
Oct 09, 2021
Position Type
Full Time
Level
Mid Level

Two postdoctoral fellow/research associate positions supported by NIH funding are available until filled in the laboratory of Professor Yongjie Yang in the Department of Neuroscience at Tufts University School of Medicine (Boston, MA) to study (astro)glia to neuron communication mechanisms in neurological diseases.

The Yang lab primarily studies neuron to glia signaling and pathogenic roles of glial mechanisms in neurological diseases/disorders. The lab employs novel genetically modified mouse and viral tools, in combination with primary glia and neuronal cultures, cell biological imaging, electrophysiological, and biochemical/molecular techniques.  More info can be found at: https://gsbs.tufts.edu/facultyResearch/faculty/yang-yongjie and

https://yongjieyang-lab.org/

In recent years, new studies from our lab and others have shown the emerging roles of secreted endosome-derived exosome signaling in physiological and pathological communication between neurons and (astro)glial cells. Our lab has developed new tools for in vivo mechanistic investigations (Nat. Comm., 2019) into how this pathway is involved in the pathological development of neurological diseases (mainly Amyotrophic Lateral Sclerosis and Alzheimer’s Disease).

In addition to the role of astrocyte to neuron communication in neurodegenerative diseases, we have also investigated developmental astroglial functions and their implication in Fragile X Syndrome (FXS), a neurodevelopmental disorder. We have established conditional Fmr1 deletion models for studying the role of Fmr1 in astrocytes, as a model to better understand how astrocytes are implicated in neurodevelopmental disorders. We have also identified new miR-based mechanisms and mRNA targets that are regulated by FMRP in astrocytes (PNAS, 2020).

Candidates who are interested in glia, especially glia to neuron communication, and their roles in neuropathological conditions are encouraged to apply. It is expected that the candidate should have a recent PhD (less than 2 years) in Neuroscience or a related discipline (Biochemistry/Cell Biology/Genetics) and is able to communicate well with others. The potential new postdoc candidate can choose to study either of the two research areas described above.

To apply, please send a CV (via e-mail) including all past education and training, a brief description of research interests, list of publications, other scientific activities, and names and e-mail addresses of three references to Dr. Yongjie Yang at: Yongjie.Yang@tufts.edu,

The Yang lab is located at Tufts Medical School in downtown Boston, near Boston’s Chinatown and the Boston Common.

Tufts University School of Medicine is an Equal Opportunity Affirmative Action Employer. Women and minorities are encouraged to apply.

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