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Research Fellow - Receptor Biophysics Laboratory

Mayo Clinic
Rochester, Minnesota
Closing date
Aug 21, 2021

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Job Function
Research Staff / Technical Director
Position Type
Full Time
Entry Level
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The Research shield at Mayo Clinic is committed to creating a diverse environment and recognizes that diverse research teams make better decisions, are more equipped to solve complex problems and adapt to change, and produce better outcomes. That diversity is about opening up to unconventional ideas that create better outcomes, while recognizing colleagues' unique contributions. Become part of the legacy that embraces these differences and enables us to provide the best care to patients from all over the world.

Mayo Clinic offers a variety of employee benefits. For additional information please visit Mayo Clinic Benefits. Eligibility may vary.

Two NIH-funded postdoctoral positions are available in the Receptor Biophysics Laboratory directed by Dr. Steven Sine within the Departments of Physiology and Biomedical Engineering and of Molecular Pharmacology and Experimental Therapeutics at Mayo Clinic in Rochester Minnesota.
     * The laboratory investigates biophysical and structural mechanisms underpinning nicotinic acetylcholine receptor function in normal and disease conditions and in the presence of small molecule modulators.
     * State of the art single channel electrophysiology is combined with mechanistic analyses and site-directed changes in receptor structure (eLife 2021, PMID 33821794; Cell 2021, PMID 33735609; J. Gen. Physiol. 2020, PMID 32702089).
     * We seek highly motivated applicants with strong quantitative skills and a desire to advance understanding of biophysical mechanisms as they relate to the structure and modulation of ion channels of therapeutic interest.

To apply for this position please send a cover letter describing research interests, past accomplishments and future goals, full CV, and contact information for three references to Dr. Steven M. Sine at

A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.

The following is required for completeness of application:
     * Current curriculum vitae with bibliography
     * Proof of doctoral degree (copy of diploma or final transcript with English translation, if applicable) or a letter from your university's Registrar office indicating you have fulfilled all doctoral program requirements and are eligible to graduate.

Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere.
  Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life.

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