Postdoctoral Position - Epigenetic Regulation in Neurodegeneration

7 days left

Desplats' Lab UCSD
San Diego, California
Salary according to expertise and following NIH guidelines.
Jul 02, 2021
Aug 01, 2021
Position Type
Full Time
Entry Level

A postdoctoral position is available immediately in Dr. Paula Desplats’ laboratory in the Department of Neurosciences, University of California San Diego.

The Desplats Lab has a postdoctoral position open for immediate starting. The lab is interested in understanding how altered epigenetic mechanisms may contribute to adult neurodegenerative disorders, and we have a long-standing trajectory on unraveling disease mechanisms associated with alpha-synuclein misfolding and accumulation (PNAS 2009, 106(31): 13010-5; JBC 2012 287(38): 31691-702), including pioneering epigenetic analysis in Parkinson’s and Alzheimer’s diseases (Epigenetics 2013, 8(10): 1030; Alzheimers Dement. 2017 13(6):689-700; Epigenetics 2019, 14(4):365-382; Alzheimers Dement 2021, 13(1):e12156). 

The study is based on modulation of DNA methylation in the context of neuroinflammation in Alzheimer’s disease, applying cellular and mouse models, CRISPR and Cre/flox tools, in addition to transcription and epigenetic analysis. Another aspect of the study is exploring epigenetic signals as biomarkers for diagnosis and disease progression, a highly-innovative and fast-paced project. 

We are looking for a self-motivated individual with strong creative and critical thinking; detail-oriented and goal-driven researcher who is an exceptional team player. 


·       Recent Ph.D. in neurosciences, molecular or cell biology.

·       Hands-on experience on cutting-edge technology for transcriptional and epigenetic analysis, like ChIP-seq; RNA-seq; ATAC-seq and similar techniques.

·       Advanced skills in tissue culture, including gene modulation and CRISPR.

·       Candidates with a proven record of proficient data analysis using complex bioinformatic pipelines will be prioritized. 

·       Expertise in mouse models of neurodegeneration, including stereotactic injections, brain sectioning and immunostaining.

·       Excellent written communication skills and team-work.

If you are interested in joining a growing and vibrant lab with a passion for translational science and to enjoy the highly collaborative neuroscience community of San Diego, please contact the PI at including c.v. and a brief description of research interests.  


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