Postdoctoral Position - Epigenetic Regulation in Neurodegeneration

7 days left

Employer
Desplats' Lab UCSD
Location
San Diego, California
Salary
Salary according to expertise and following NIH guidelines.
Posted
Jul 02, 2021
Closes
Aug 01, 2021
Position Type
Full Time
Level
Entry Level

A postdoctoral position is available immediately in Dr. Paula Desplats’ laboratory in the Department of Neurosciences, University of California San Diego.

The Desplats Lab has a postdoctoral position open for immediate starting. The lab is interested in understanding how altered epigenetic mechanisms may contribute to adult neurodegenerative disorders, and we have a long-standing trajectory on unraveling disease mechanisms associated with alpha-synuclein misfolding and accumulation (PNAS 2009, 106(31): 13010-5; JBC 2012 287(38): 31691-702), including pioneering epigenetic analysis in Parkinson’s and Alzheimer’s diseases (Epigenetics 2013, 8(10): 1030; Alzheimers Dement. 2017 13(6):689-700; Epigenetics 2019, 14(4):365-382; Alzheimers Dement 2021, 13(1):e12156). 

The study is based on modulation of DNA methylation in the context of neuroinflammation in Alzheimer’s disease, applying cellular and mouse models, CRISPR and Cre/flox tools, in addition to transcription and epigenetic analysis. Another aspect of the study is exploring epigenetic signals as biomarkers for diagnosis and disease progression, a highly-innovative and fast-paced project. 

We are looking for a self-motivated individual with strong creative and critical thinking; detail-oriented and goal-driven researcher who is an exceptional team player. 

Qualifications

·       Recent Ph.D. in neurosciences, molecular or cell biology.

·       Hands-on experience on cutting-edge technology for transcriptional and epigenetic analysis, like ChIP-seq; RNA-seq; ATAC-seq and similar techniques.

·       Advanced skills in tissue culture, including gene modulation and CRISPR.

·       Candidates with a proven record of proficient data analysis using complex bioinformatic pipelines will be prioritized. 

·       Expertise in mouse models of neurodegeneration, including stereotactic injections, brain sectioning and immunostaining.

·       Excellent written communication skills and team-work.

If you are interested in joining a growing and vibrant lab with a passion for translational science and to enjoy the highly collaborative neuroscience community of San Diego, please contact the PI at pdesplat@uscd.edu including c.v. and a brief description of research interests.  

 

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