Postdoctoral fellow in precision medicine and ion channel electrophysiology
ABOUT THE BROAD/STANLEY CENTER
The mission of the Stanley Center for Psychiatric Research at the Broad Institute is to discover novel therapeutics to ameliorate the burden of major psychiatric illnesses including schizophrenia, bipolar disorders and autism spectrum disorders. We exploit the emerging human genetics in the pathogenesis of psychiatric diseases as an effective window to study their biology and as clues for new therapeutics.
The candidate will implement cellular and electrophysiological assays to lead the study on the impact of genetic variants of the candidate risk genes associated with neurological and psychiatric disorders. The candidate will utilize an array of techniques including electrophysiology, RNA-sequencing, pharmacology, and cell biology to analyze genetic variants of ion channels and other membrane proteins and dissect the role of such variations in the disease pathogenesis in vitro and in vivo. Furthermore, the candidate will be expected to provide domain expertise in the interdisciplinary project teams aiming to develop novel therapeutics for severe mental disorders. The researcher will be responsible for communicating results to the scientific community through conference presentations and publications, and within Broad Institute internal communications.
- Ph.D. in Neuroscience, Cell biology or related field with solid training in in vitro electrophysiology and ion channel physiology. Demonstrated technical proficiency in whole cell patch clamp recordings in cultured cells or brain slices.
- Proficient in cell biology and biochemical assays including protein stability analyses and membrane protein trafficking assays. Understanding of human genetics is a plus.
- Proven record of first author publications. Outstanding personal initiative and communication skills, to work in a collaborative environment.
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