This job has expired

Postdoctoral fellow or Research Associate in Nerve Regeneration

Employer
Shriners Research Center for Neural Repair at Temple University School of Medicine
Location
Philadelphia, Pennsylvania
Salary
NIH scale
Closing date
Aug 28, 2021
You need to sign in or create an account to save a job.

Job Details

Looking for highly motivated postdoctoral fellow(s) for a project associated with spinal cord or peripheral nerve regeneration or Schwann cell myelination to extend the following, recent findings of Son laboratory.

(1) TEAD1 predominently mediate YAP/TAZ to devep and repair Schwann cell myelination. Grove M...Son YJ (in preparation)

(2) Oligodendrocyte progenitors synaptogenetically stop sensory axons regenerating into the spinal cord. Kim H...Son YJ (in preparation)

(3) Co-targeting BRAF and PTEN in IB4+ neurons drives topographic and functional regeneration of broad sensory neurons. Kim H, Noristiani H...Son YJ (in preparation)

(4) Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord.  Zhai J...Son YJ, eLIFE 2021 DOI: 10.7554/eLife.63050

(5) Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury. Grove M...Son YJ, Elife. 2020 doi: 10.7554/eLife.50138.

(6) YAP/TAZ initiate and maintain Schwann cell myelination. Grove M...Son YJ, Elife. 2017 doi: 10.7554/eLife.20982.

Using mice, we apply microsurgery, widefield and multiphoton in vivo imaging, conditional/inducible transgenic mice, in vivo AAV or lenti viral transduction, neuronal and glial cell cultures, electrophysiology, TEM/SEM, confocal microscopy, behavioral analysis of motor and sensory functions, IP, Chip-seq, proteomics or RNAseq profiling. Applicants must be competent with at least some of these techniques and have a prior research experience with axon regeneration, Hippo signaling, SC myelination, OPCs, viral gene therapy or Schwannoma cancer biology.

Our Center is focused on spinal cord and peripheral nerve regeneration offering excellent training opportunity for students in the field. Salary will follow NIH scale with excellent benefit package.

https://medicine.temple.edu/departments-centers/research-centers/shriners-hospitals-pediatric-research-center/faculty

Please email a cover letter (briefly mentioning your previous experience), CV and names of three referees, to Dr. Son.

Young-Jin Son, PhD

Professor of Dept. Neural Sciences

Shriners Hospitals Pediatric Research Center

Lewis Katz School of Medicine, Temple University

3500 N Broad St.

Philadelphia, PA 19140

yson@temple.edu

Shriners Hospitals Pediatric Research Center is a collaboration between Shriners Hospitals for Children® and Temple University School of Medicine.  Temple University is an EEO/AA employer and strongly encourages applications from women and minorities.  Further information about Temple University School of Medicine is available at http://www.medschool.temple.edu/

Company

Shriners Hospitals Pediatric Research Center (SHPRC) The Shriners Hospitals Pediatric Research Center (Center for Neural Repair and Rehabilitation) is a collaboration between the Shriners Hospitals for Children and Temple University School of Medicine. The Center opened in October 2009 in Temple’s brand new Medical Education and Research Building (MERB), where it occupies the entire 6th floor (23,000 usable square feet). Our mission is to do research that will develop therapies for injuries to the nervous system, focusing on mechanisms of neural repair and plasticity. The Center currently has 10 principle investigators to make up 3 interactive and cross-fertilizing research teams – a Spinal Cord Injury Research Team, a Peripheral Nerve Injury Research Team, and a Brain Injury Research Team.
Find Us
Telephone
(215)926-9354
Location
Temple University Sch Med
3500 N Broad St
Philadelphia
PA
19140
US
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert