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Research Scientist, Electrophysiology

Xenon Pharmaceuticals Inc.
Greater Vancouver, British Columbia (CA)
Annual Salary + benefits
Closing date
Jul 23, 2021

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Job Details

Xenon Pharmaceuticals (NASDAQ:XENE) – a biopharmaceutical company with operations in Vancouver, BC, Canada and Boston, MA, USA – is advancing an exciting pipeline of therapies for neurological disorders, with a particular focus on innovative treatments for epilepsy. 

Xenon has a number of promising therapeutics in clinical development, valuable collaborations with pharmaceutical partners, and innovative early-stage research underway and also has a strong balance sheet to support its continued growth in 2021 and beyond. 

We are a collaborative, ambitious, and driven team with a common mission to improve the lives of patients with neurological disorders. Creating a healthy and productive work environment is a priority, and we understand the importance of investing in our employees’ growth and development. We support charities and volunteerism, knowing that when our people contribute to their local communities, they are gaining new experiences and becoming even better leaders. Xenon’s employees are smart, passionate, and driven by their incredibly important work to discover, develop and deliver new medicines for patients in need. We are looking for talented and determined individuals who thrive in a fast-paced and dynamic work environment to join our team during this transformative time for the company. If you want to learn more about job opportunities at Xenon, please visit

We are seeking a Research Scientist, Electrophysiology to join our team. We are in search of a highly motivated and creative electrophysiologist who will contribute to characterizing and elucidating the effects of novel agents on the function of target ion channels. The primary role will be to develop and run electrophysiological assays using techniques including automated high throughput planar patch clamp systems and manual patch clamp electrophysiology. The candidate must have extensive experience in the functional study of ion channels and voltage clamp electrophysiology. In addition, this scientist will devise and conduct experiments to deepen our understanding of compound mechanism of action on our targets of interest. Our intent is to identify a scientist with the potential to actively and independently evaluate and drive new avenues of research. Expertise in electrophysiology and biophysics is essential. This is an opportunity to work with cutting edge electrophysiology platforms and collaborate with a wide ranging electrophysiology team utilizing multiple techniques including MEA and slice. The successful candidate will join a passionate, diverse, and dynamic team focused on developing treatments for epilepsy and other neurologic indications. 

Reporting to the Principal Scientist, Electrophysiology, this position will be located in the Vancouver area, BC, Canada; relocation and immigration support will be provided if required.


  • Develop, implement and validate new assays of excitable cell function both independently and as part of a larger team.
  • Timely delivery of data and interpretation to drive and inform project team directions.
  • Active participation and presentation at group and project meetings.
  • Coordination and documentation of datasets to support internal decision making as well as external publications and regulatory filings.
  • Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices. 
  • Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.


  • Ph.D. or commensurate experience in ion channel biophysics, neuroscience, pharmacology or related field and can display an in depth knowledge of voltage-clamp electrophysiological techniques.
  • Experience investigating ion channel function and/or pharmacology electrophysiologically and creatively quantifying effects in these assays.
  • Excellent analytical skills allowing for qualitative and quantitative evaluation of complex systems and datasets and distillation of that data into clear, insightful interpretations.
  • Experience handling and managing large datasets.
  • Enthusiasm for laboratory work and good problem solving abilities.
  • Ability to work in a dynamic and enthusiastic team environment is critical.
  • Excellent oral and written communication skills and takes initiative. 
  • Excellent record keeping and attention to detail. 
  • An adaptable mindset with the ability to adapt to rapidly changing projects and priorities.

To apply for this position, visit our job posting and click ‘Apply Now’. We thank all applicants for their interest; however, due to the volume of applicants, only those chosen for interview will be contacted.


We are a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological disorders, including rare central nervous system (CNS) conditions. Xenon is advancing a novel product pipeline of neurology therapies to address areas of high unmet medical need, with a focus on epilepsy.
Find Us
7540 19th Ave
V3N 1E6
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