The laboratories of Ethan Goldberg (goldbergneurolab.com) and Stewart Anderson (stewandersonlab.research.chop.edu) at The Children’s Hospital of Philadelphia/University of Pennsylvania have a postdoctoral fellowship position available to study mechanisms of neurodevelopmental disorders in experimental model systems. The project involves
human stem cell differentiation into cerebral cortex neurons (excitatory and inhibitory 2-D cultures and organoids), and detailed study via a range of techniques including electrophysiology, imaging, optogenetics, histology, and single-cell transcriptomics.
Desired Skills and Experience
Recent graduate with a Ph.D. in neuroscience, developmental biology, or related/applied field. Prior basic experience with electrophysiology, cell culture (preferably ES/iPS cells), imaging, and/or single cell biology, is required.
Applicants should submit a CV, statement of research interests, and contact information for three references by email to: Ethan Goldberg at firstname.lastname@example.org
About the Employer
Dr. Goldberg is Assistant Professor in the Departments of Neurology and Neuroscience at The University of Pennsylvania and The Children’s Hospital of Philadelphia and opened his lab in July 2015; he directs the Epilepsy NeuroGenetics Initiative at CHOP. Dr. Anderson is Professor of Psychiatry at The University of Pennsylvania and The Children’s Hospital of Philadelphia.
Recent publications of relevance include:
-- Tyson J.A., Goldberg E.M., Maroof A.M., Xu Q., Petros T.J., Anderson S.A. (2015). Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development 142:1267-1278. PMC4378243.
-- Favero, M., Sotuyo, N.P., Lopez, E., Kearney, J.A., Goldberg, E.M. (2018). A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome. J Neurosci. 38(36):7912-7927. PMC6125809.
-- Goff, K., and Goldberg, E.M. (2019). Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome. Elife. Jul 8;8. pii: e46846. PMC6629374.
-- Li, J., Ryan, S., Deboer, E., Cook, K., Fitzgerald, S., Lachman, H., Wallace, D., Goldberg, E.M., Anderson, S.A. (2019). Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia. Transl Psych 9(1):302. PMC6861238.
-- Chu, J., Fitzgerald, M.L., Sehgal, N., Manley, W., Fitzgerald, S., Naung, H. Goldberg, E.M., Anderson, S.A. Enhanced maturation of human stem cell derived interneurons by mTOR activation. biorXiv doi: https://doi.org/10.1101/777714, 2019.
-- Tran, C., Vaiana, M., Nakuci, J., Somarowthu, A., Goff, K.M., Goldstein, N., Murthy, P., Muldoon, S.F., Goldberg, E.M. (2020). Interneuron desynchronization precedes seizures in a mouse model of Dravet syndrome. J Neurosci. 40(13):2764-2775. PMC7096149.
-- Zaman, T., Helbig, K., Clatot, J., […] Goldberg, E.M. (2020). SCN3A-related neurodevelopmental disorder: A spectrum of epilepsy and brain malformation. Ann Neurol. 2020 Aug;88(2):348-362. PMID: 32515017.