Senior Researcher - Department of Pharmacology
University of Minnesota Medical School
Senior Researcher - Researcher 5 Department of Pharmacology
• Applicants must possess an advanced degree (PhD or MD/PhD) in biomedical sciences with 1 or more years of research training
• Experience in managing lab routines
• Demonstrated publication record with multiple first-author papers in reputable journal
• Effective oral and written communication skills
About the Job
• Designs, plans, and implements complex research experiments in studying hormone signaling in diseases (neurodegenerative, motor neuron and inflammatory diseases)
-molecular signaling of hormones, such as retinoic acid, using modern techniques in molecular, cell biology, biochemistry, genetics, neuron science, and bioinformatics
-in vivo (mouse dissection, surgery, imaging and virus packaging techniques)
-in vitro (molecular, biochemical, primary culture, cell line, FLOW, fluorescence and confocal microscopy)
• Remains current on technological and scientific developments in the field and their potential application into experimental plans
• Interacts, communicates, and coordinates with lab members to complete research projects
• Carries out experiments independently from start to finish, trouble shoots, and optimizes methods and reports data
• Rapidly acquires knowledge of new methods as needed to complete projects
• Analyzes, interprets and presents experimental results and performs statistical analyses to Dr. Wei
• Assist with overseeing and managing the lab and lab equipment, lab staff, and students. Tasks may also include general laboratory operation and maintenance and miscellaneous duties as assigned.
• Maintenance of animal colonies
• Prepares manuscripts and figures for publication
• Use a range of information resources beyond the primary literature, e.g., public databases
About the Department
The Wei lab is interested in regulatory pathways and underlying mechanisms in diseases related to the endocrine system, innate immunity and brain/neuron functions. Key targets of investigation are: a) hormone (vitamin A) signaling pathways that involve nuclear receptors and coregulators (chromatin remodeling), and b) extra-nuclear signals for post-transcriptional events (cytoplasmic signalsome, exosome, RNA transport and translation). Major experimental systems include genetic mouse models (CRISPR-edited), as well as in vitro models using primary neuron, macrophage, adipocyte and embryonic stem cell. Integrated methodologies include molecular, biochemical, immunological and neurological techniques. The ultimate goal is to understand disease mechanism for therapeutics development. Recent emphases are placed on a) identifying new therapeutic targets of inflammatory diseases (macrophage malfunction) and neurological diseases (neuronal stress and motor neuron diseases related to neuromuscular junction defects), and b) developing small molecular therapeutics for these diseases. Li-Na Wei, PhD, Distinguished McKnight University Professor
How to Apply
Applications must be submitted online, please visit our Careers page and search Job ID# 340050. To be considered for this position, please click the Apply button and follow the instructions. You will have the opportunity to complete an online application for the position and attach a cover letter and resume.
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About the U of M
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.