Post-Doctoral Research Fellow: Circadian Rhythms in Neuronal Models of Bipolar Disorder

San Diego, California
Based on experience, local and NIH regulations
Feb 24, 2021
Apr 25, 2021
Position Type
Full Time
Entry Level

The laboratory of Michael McCarthy MD, PhD seeks an energetic and motivated post-doctoral research fellow to join the team in the Spring/Summer 2021. The overall goals of the project are to develop novel cellular models of bipolar disorder using iPSC-derived neurons and use this platform to identify and characterize differences in circadian rhythms that distinguish patients with bipolar disorder from controls and inform treatments with mood stabilizer medications like lithium. Leveraging data from clinical treatment trials and genetic family studies, the project will make use of well-described cohorts of bipolar disorder patients and genetically related healthy subjects. We use viral vectors to express circadian reporter genes in neurons and measure rhythms longitudinally in live cultures and single cells. We characterize the circadian clock further using genomic, physiological and structural approaches to characterize neurons. The project will be an excellent opportunity for a neurobiology researcher to pursue novel applications of cutting-edge biology and explore an area with extraordinary potential for clinical translation.

The research is funded by the Department of Veterans Affairs and housed in at the VA San Diego Medical Center, adjacent to the UCSD main campus.  An academic appointment will be made through the UCSD Department of Psychiatry, one of the top translational neuroscience research programs in the country. Fellow will be affiliated with the UCSD Center for Circadian Biology, an internationally recognized research center, providing additional resources for career development and a rich training environment.

• PhD degree in a relevant biological science (neuroscience, molecular biology, genetics etc.)
• At least 3 years of biomedical laboratory experience
• Previous experience in stem cell biology, molecular biology, gene editing/gene knockdown, and bioinformatics are highly desirable.
• Strong track-record of research productivity.
• Excellent communication skills, works well in teams, and demonstrates effective skills in time management and organization.
• The successful applicant will meet all eligibility requirements for employment at UCSD and the VA San Diego including US visa status and successful completion of a background check.
• Applicants from under-represented minority groups are especially encouraged to apply.

Compensation: Salaries are competitive and determined based on the experience of the applicant in accordance with NIH and UCSD post-doc union guidelines.

Location: San Diego, CA is a large and vibrant city and a hub of activity for biotechnology with a year-round temperate climate. VA San Diego/UCSD is located in La Jolla CA, close to beautiful beaches, and parks and offers a wide range of cultural, recreational and social opportunities.

Application: Interested applicants should send an email to Dr McCarthy: that includes the following information: CV, cover letter, and contact information for at least three references willing to write a letter of support.


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