Postdoctoral Fellow

Location
San Diego, California
Salary
NIH standard
Posted
Feb 22, 2021
Closes
Apr 23, 2021
Position Type
Full Time

Postdoctoral Fellow Positions

Postdoc positions are available at University of California, San Diego in the laboratory of Yimin Zou. The following is a list of scientific questions we are currently addressing and the technologies being used in these projects:

  1. Axon guidance and central nervous system repair

What are the genetic programs for wiring major axon diagrams? How are axon guided to their targets? What are the roles of axon guidance molecules in adult CNS injury and degeneration? How is glial scar formation regulated? How do neural circuits reorganize themselves to achieve functional recovery?

CRISPR-Cas9 strategies, single cell transcriptomics, mass spectrometry, super resolution microscopy, light sheet microscopy, organotypic cultures, spinal cord and brain injury models, behavioral studies for functional recovery, miniature scope, single cell transcriptomics and viral tracing and 3D imaging of axons.

  1. Synapse formation and synaptopathy in neurodegeneration and neuropsychiatric disorders

Is there a common signaling pathway for the formation and maintenance of all glutamatergic synapses? How synaptic recognition molecules interact with the synapse formation pathway? How abnormal synapse development leads to developmental and neuropsychiatric disorders? How synapse loss occurs in neurodegenerative disorders?

Electrophysiology, electron microscopy, two-photon imaging, miniature microscope, fiber photometry, CRISPR-Cas9 strategies, behavioral tests (cognitive, social and emotional), viral approaches to target neuronal types, single cell transcriptomics and mass spectrometry.

Please contact Yimin Zou (yzou@ucsd.edu)

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