Postdoctoral Fellow–Molecular Neurobiology, Huntington's disease pathogenesis

Saint Louis, Missouri
Commensurate with experience
Feb 12, 2021
Apr 13, 2021
Position Type
Full Time

The Yano lab at Washington University School of Medicine in St. Louis and the Hope Center for Neurological Disorders has an immediate opening (beginning Spring/Summer 2021) for a highly motivated postdoctoral candidate to investigate the molecular mechanisms that drive neuronal dysfunction and death in neurodegenerative diseases, in particular, in Huntington’s disease (HD).  Our ultimate research goal is to identify the key disease mediator(s), which can be therapeutically targeted.  We utilize primary neuron cultures, in vivo mouse models of the disease, and an array of molecular biology, biochemistry and cell biology approaches.  

This position will focus on the lab’s NIH-funded research projects. The primary focus of the work will include, but is not limited to:

  • Determining the role of DNA methyltransferases in neuronal dysfunction and death in HD.
  • Identifying the molecular mechanisms of epigenetic deregulation in HD.
  • Developing novel neuroprotective therapeutics for HD and other related neurodegenerative disorders.
  • Developing reliable noninvasive biomarkers for HD using preclinical mouse models.


Primary duties & responsibilities:

  1. Collaborates with PI on the design, conduct and reporting of research projects.
  2. Maintains comprehensive knowledge of the advances in specialized fields.
  3. Keeps/organizes experimental records, data, and required documentation on laboratory.
  4. Positive engagement in learning and career development of self and others.

Candidates with significant experience in epigenetic gene regulation, signal transduction molecular biology, biochemistry, cell culture, and animal experiments are strongly preferred.  Interested candidates with relevant qualifications should email curriculum vitae, including a summary of their research, list of publications, and contact information for three recent references, to Hiroko Yano, PhD, at

Required Qualifications: Ph.D. and/or M.D. with experience in neuroscience/neurodegenerative disease research, molecular biology, biochemistry, and cell biology.  Ability to work independently and in a highly collaborative, multidisciplinary environment with strong communication, interpersonal skills, and good organization skills is required. 

Preferred Qualifications: Significant experience in epigenetic gene regulation, signal transduction, molecular biology, cell cultures, and mouse handling/animal experiments. New graduates or postdocs with 3 or fewer years of experience.

Washington University School of Medicine: The laboratory of Hiroko Yano, PhD in Neurological Surgery, Neurology, and Genetics is located in Couch Biomedical Research Building at Washington University School of Medicine ( Washington University School of Medicine consistently ranks in the top 10 medical schools in the United States and is home to many of the United States' top scientists and physicians. Washington University School of Medicine provides a highly collaborative environment among different departments.


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