Postdoctoral fellowship in neuroscience
Positions are available for a postdoctoral fellow in the laboratory of Dr. Amy Lee, PhD in the Dept. of Neuroscience at the University of Texas-Austin (https://neuroscience.utexas.edu/component/cobalt/item/17-neuroscience/4258-lee-amy?Itemid=1258). We are broadly interested in the Ca2+ signaling mechanisms that control the development, function, and repair of the nervous system. Our current areas of research include:
- Structure/function relationships of voltage-gated (Cav) Ca2+ channels: We are studying the molecular determinants and protein interactions that regulate the biophysical properties of Cav channels. Technical approaches include patch-clamp electrophysiology, voltage-clamp fluorometry, FRET, and isothermal titration calorimetry. A major goal of this project is to generate modified Cav channels to study their roles within neuronal cell-types and circuits.
- Ca2+ signaling mechanisms controlling axonal regeneration: We are investigating a novel pathway involving Cav channels and calmodulin-like Ca2+ binding proteins (CaBPs) in sensory neurons. We are determining how Cav coupling to CaBPs alters the regenerative growth of axons in vitro, and the recovery of sensory function following nerve injury in vivo. Techniques include live-cell imaging, single-cell RNAseq, and machine-learning approaches for analyzing neuronal morphology.
- Cav and other ion channels and retinal circuit development and function: We are investigating the roles of Cav channel subtypes in regulating photoreceptor synapse assembly, and how dysregulation of these channels lead to aberrant and homeostatic forms of rewiring within retinal circuits. Techniques include multi-photon imaging/electrophysiology in retinal tissue, behavioral analyses of visual function, and imaging (super-resolution and electron microscopy) of protein localization and synaptic structure.
Responsibilities include leading a research project through publication, attending lab meetings and departmental seminars/workshops, mentoring graduate and/or undergraduate students, and assisting in grant-writing and developing new research directions. Successful candidates will have a PhD in the neurosciences or relevant field, a strong record of productivity, excellent communication (written and verbal) skills, and an ability to work in, foster, and advocate for a diverse, multi-cultural environment. Experience in molecular biology, patch-clamp electrophysiology, and optical imaging in various preparations is highly desirable.
The Dept. of Neuroscience at UT-Austin provides a highly collaborative environment with research strengths in ion channels, learning/memory, and sensory neuroscience (https://neuroscience.utexas.edu). The university is situated near downtown Austin, which has been consistently ranked the #1 best cities in which to live in the US (https://realestate.usnews.com/places/texas/austin).
Interested candidates should send CV and statement of interest to Amy Lee (firstname.lastname@example.org).
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