Postdoctoral fellowship in neuroscience

Positions are available for a postdoctoral fellow in the laboratory of Dr. Amy Lee, PhD in the Dept. of Neuroscience at the University of Texas-Austin (https://neuroscience.utexas.edu/component/cobalt/item/17-neuroscience/4258-lee-amy?Itemid=1258). We are broadly interested in the Ca²⁺ signaling mechanisms that control the development, function, and repair of the nervous system. Our current areas of research include:

1. Structure/function relationships of voltage-gated (Ca_v) Ca²⁺ channels: We are studying the molecular determinants and protein interactions that regulate the biophysical properties of Ca_v channels. Technical approaches include patch-clamp electrophysiology, voltage-clamp fluorometry, FRET, and isothermal titration calorimetry. A major goal of this project is to generate modified Ca_v channels to study their roles within neuronal cell-types and circuits.

1. Ca²⁺ signaling mechanisms controlling axonal regeneration: We are investigating a novel pathway involving Ca_v channels and calmodulin-like Ca²⁺ binding proteins (CaBPs) in sensory neurons. We are determining how Ca_v coupling to CaBPs alters the regenerative growth of axons in vitro, and the recovery of sensory function following nerve injury in vivo. Techniques include live-cell imaging, single-cell RNAseq, and machine-learning approaches for analyzing neuronal morphology. 

1. Ca_v and other ion channels and retinal circuit development and function: We are investigating the roles of Ca_v channel subtypes in regulating photoreceptor synapse assembly, and how dysregulation of these channels lead to aberrant and homeostatic forms of rewiring within retinal circuits. Techniques include multi-photon imaging/electrophysiology in retinal tissue, behavioral analyses of visual function, and imaging (super-resolution and electron microscopy) of protein localization and synaptic structure.

Responsibilities include leading a research project through publication, attending lab meetings and departmental seminars/workshops, mentoring graduate and/or undergraduate students, and assisting in grant-writing and developing new research directions. Successful candidates will have a PhD in the neurosciences or relevant field, a strong record of productivity, excellent communication (written and verbal) skills, and an ability to work in, foster, and advocate for a diverse, multi-cultural environment. Experience in molecular biology, patch-clamp electrophysiology, and optical imaging in various preparations is highly desirable.

The Dept. of Neuroscience at UT-Austin provides a highly collaborative environment with research strengths in ion channels, learning/memory, and sensory neuroscience (https://neuroscience.utexas.edu). The university is situated near downtown Austin, which has been consistently ranked the #1 best cities in which to live in the US (https://realestate.usnews.com/places/texas/austin).

Interested candidates should send CV and statement of interest to Amy Lee (amy.lee1@austin.utexas.edu).