Postdoctoral research fellow
The Department of Neurological Surgery at IU School of Medicine has an open post-doctoral position for candidates interested in translational research investigating the development of epilepsy and neuronal plasticity in a mouse model of temporal lobe epilepsy. You will join a highly collaborative group with extensive resources and techniques to investigate the development of temporal lobe epilepsy and the role of the Wnt pathway in modulating epileptogenesis. Specific investigative aims include, i) genetic dysregulation in the temporal lobe, ii) structural plasticity after the development of epilepsy, iii) electrographic recording of the brain in early epileptogenesis. Some of the techniques used in this project include animal stereotactic surgery, behavioral epilepsy scoring, microdissection, brain-slicing, DNA/RNA isolation, whole animal electrocorticography, confocal microscopy. Transgenic mice lines will be used for scientific inquiry, future lines of investigation may include human post-surgical tissue.
Environment: The laboratory is located in the vibrant scientific environment of the Stark Neurosciences Research Institute in the Neuroscience Research Building (https://medicine.iu.edu/research-centers/neurosciences). The position is situated in the laboratories of Dr. Kunal Gupta and Dr. Xiao-Ming Xu, Spinal Cord and Brain Injury Research Group. Instruments and techniques are established for stereotactic surgery, RNA isolation, confocal and 2-photon microscopy, extensive behavioral lab, wireless ambulatory electrocorticography, viral transfection and more. The vivarium is located adjacent to the research space. Highly collaborative groups throughout the building, an ideal training ground for post-docs pursuing a career in academia or industry. Stark Neurosciences Research Institute is also home to the Stark Postdoctoral Association (SPA) in which the incumbent will have the opportunity to join, participate in activities and benefit from available resources.
At the IU School of Medicine, we offer focused, systematic and sustained programs that are aligned with three foundational pillars of diversity and inclusion: representational diversity, inclusive working and learning environment, and cultural competence. Therefore, we are looking for applicants who can help ensure all our mission areas are inclusive and equitable.
Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named “Best Airport in North America” by Airports Council International for many years.
Candidates with a recent PhD in neuroscience, molecular biology, cell biology, structural biology, developmental biology or related disciplines, skilled in mouse handling and husbandry, highly motivated to work independently and within a collaborative environment. Experience with confocal-microscopy, immunohistochemistry, RNA isolation, western blot is desirable. Compensation is commensurate with experience, based on the NIH stipend.