Postdoctoral fellowship in multimodal neuroimaging

Employer
University of Maryland Baltimore
Location
Baltimore, Maryland
Salary
Up to $46,000 per year + benefits
Posted
Oct 07, 2020
Closes
Nov 06, 2020
Position Type
Full Time
Level
Entry Level

Postdoctoral fellowship in multimodal pain neuroimaging at University of Maryland Baltimore

A postdoctoral position is available immediately under our new grant “Novel target identification for treatment of chronic overlapping pain using multimodal brain imaging.” The position is in the lab of Dr. David Seminowicz www.daslab.org and is part of a collaborative project led jointly by Drs. Richard Traub and Ohannes Melemedjian from the Department of Neural and Pain Sciences, as well as investigators in the Department of Microbial Pathogenesis.

Project summary: the objective of this project is to identify novel targets for non-addictive pharmacological treatment of multiple types of pain symptomatic of chronic overlapping pain conditions. Rats can be induced to develop chronic visceral and orofacial pain hypersensitivity, modeling pain reported by patients with irritable bowel syndrome and temporomandibular disorder. Furthermore, pain is more robust in females, mirroring sex differences in patients. Using the stress-induced and comorbid pain models, visceral and orofacial pain sensitivity will be measured. Functional imaging (fMRI) will identify changes in brain activity and connectivity over time and mass spectroscopy imaging of brain tissue (MSI) will identify specific lipids and metabolites that change expression, correlating with changes observed by fMRI. Specifically, we expect to see altered brain activity in the insula cortex, the medial prefrontal cortex, the amygdala and the hippocampus. Changes in lipid expression and metabolism will be used to identify novel targets for pain therapy. Genetic manipulation will test the role of specific lipids and metabolic enzymes in pain hypersensitivity. Targets will be further validated by a pharmacological approach. This project will address the unmet need of identifying and validating new therapeutic targets for pain hypersensitivity characteristic of chronic overlapping pain conditions.

In addition, depending on the applicant’s interests and strengths, the position could include human subject research in other areas in the lab, including:

  • Multimodal MRI of brain mechanisms of and interventions for chronic pain (fMRI, DTI, MRS, ASL, structural)
  • Studies on the interactions of pain and cognition in acute and chronic pain (fMRI, EEG, and simultaneous EEG-fMRI)

The University of Maryland offers competitive compensation and benefits for postdocs. Applicants must hold a PhD or MD plus some research experience. Neuroimaging experience is strongly preferred.

For informal inquiries or to apply, please email dseminowicz@umaryland.edu. Applications should include a CV, cover letter, research interests, and contact information for at least three references.

 

 

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