Postdoctoral fellow

The Pitt laboratory is looking for a talented senior postdoctoral fellow with strong background in glial biology and histology, and good publication record to join our team. We conduct translational research in multiple sclerosis (MS) with the goal of understanding the mechanisms that underlie MS progression and neurodegeneration. The candidate will drive two projects that involve (i) highly multiplexed histological imaging (staining of individual tissue sections with 40+ antibodies) in combination with an advanced computational pipeline for spatial analysis and (ii) transcriptomic and genomic profiling of astrocyte nuclei from MS, Alzheimer's and Parkinson’s CNS to identify genetic risk variants that dysregulate astrocyte function in these disease.

In addition to highly multiplexed imaging, our laboratory uses several cutting-edge technologies including generation of iPSC-derived astrocytes and microglia from MS patients, CRISPR/Cas9 genome editing of iPSCs, purification and quantification of exosomes from patient plasma and purification of astrocyte and oligodendrocyte nuclei from MS, Alzheimer's, and Parkinson's tissue for sNuc-Seq and ATAC-Seq. Our laboratory is part of the Department of Neurology, Yale School of Medicine, and is embedded in a highly collaborative, translational neuroimmunology program that includes T cell biology, genetics and computational biology.

The candidate should have a broad neurobiology background and experience with glial cell culture and CNS histopathology is desirable. Please respond with CV, a short description of relevant expertise, representative publications and the names of three references by email to david.pitt@yale.edu. The successful candidate can join my laboratory for a minimum of 2 years on a NIH funded position as early as 12/2020.