Post-doctoral fellow in neuroregulation and traumatic brain injury research

Univ of TX Health San Antonio
San Antonio, Texas
NIH Scale
Mar 10, 2020
May 09, 2020
Position Type
Full Time

This posting is to fill open positions in our National Institutes of Health (NIH) T32 post-doctoral training grant, “The Pathophysiology of Occlusive Vascular Disease,” in the laboratory of Mark S. Shapiro, Ph.D. in the Department of Cell & Integrative Physiology. We study the physiology, regulation, and functional role in cerbro-vascular and neurological disease, of a variety of ion channels in neurons, smooth muscle and other excitable cells, using a range of cutting-edge molecular, cellular and integrative approaches. This T32 training grant that Dr. Shapiro participates in has produced many NRSA F32-funded investigators who have gone on to successful faculty positions.  The positions should be filled by the end of July, 2020.  Candidates must have a Ph.D. or M.D. in a relevant discipline, obtained no longer than four years before the start of their fellowship.

In my group, previous and current post-docs supported by this T32 training grant have studied, or are studying, the roles of KCNQ potassium ion channel activity in neurons of the brain as a neuroprotective mechanism against brain damage induced by stroke, traumatic brain injury (TBI), and epileptic seizures leading to epileptogenesis.  We use whole-animal in vivo TBI and stroke models in a variety of wild-type or genetically-altered mice, and study the brain using brain-slice electrophysiology, immunochemistry, in vivo confocal imaging and in vivo behavioral assays.  We are very physiological and quantitative in approach, yet with strong translational relevance and potential. The candidate can thus learn patch-clamp methods and innovative imaging (deep brain to single-cell) techniques, in conjunction with molecular and live-animal behavioral approaches.  T32-supported candidates benefit from a number of grant-writing and career-building workshops given by the Office of Postdoctoral Affairs, which have proven extremely valuable as post-doctoral fellows progress to independence.  We also employ super-resolution microscopy, molecular biology, biochemistry patch clamp of tissue-culture cells and dissociated neurons to discover the intracellular 2nd-messengers that couple receptors to alterations in ion channel activity and cellular function.

To apply, please email Dr. Shapiro at UTHSA is a leading academic research university, and the Department of Cell and Integrative Physiology in the School of Medicine contains a vibrant mix of neuroscientists, cellular/molecular physiologists and integrative systems scientists who interact often and well.  The Shapiro lab at UTHSA is part of an interdepartmental and collaborative group of funded and productive neuroscientists and cardiovascular researchers.  San Antonio is a vibrant and multi-cultural city with many attractions, and offers a very affordable cost of living for a post-doctoral fellow supported by this T32 training grant.

We seek highly-motivated and hard-working candidates with strong scholarly outlook, and a keen desire to perform cutting-edge biomedical research.  A background in neurophysiology, brain damage and injury, mammalian models and ion channel physiology/pharmacology is preferred, but all candidates will be considered.  Since these are NIH T32-supported positions, US citizenship or permanent residency status is required.

All postdoctoral appointments are designated as security sensitive positions.

The University of Texas Health San Antonio is an Equal Employment Opportunity/Affirmative Action Employer, including protected veterans and persons with disabilities.

Ph.D. or M.D. in Physiology, Pharmacology, Neuroscience, Neurophysiology or relevant discipline. Experience in neuroscience, ion channel physiology/pharmacology or brain-injury research. US Citizen or Permanent Resident.

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