Postdoctoral Fellow - Neuroscience and Stem Cells
The laboratory of Dr. Buz Jinnah (http://pharmacology.emory.edu/hess-jinnah/) at Emory University School of Medicine Departments of Neurology and Human Genetics in Atlanta, GA is seeking a postdoctoral fellow interested in using human induced pluripotent stem cells (iPSCs) to study molecular mechanisms in neurogenetic disease.
The lab has an open position to study the mechanisms responsible for neuronal dysfunction in Lesch-Nyhan Disease, an X-linked disease with characteristic neurobehavioral abnormalities. This disease is caused by mutations in the HPRT1 gene, which encodes the hypoxanthine-guanine phosphoribosyltransferase enzyme. This enzyme is expressed in nearly all cells and plays a well-characterized role in purine biochemistry that involves recycling free bases and maintaining nucleotide pools which are important for energy homeostasis, DNA and RNA synthesis, intra- and inter-cellular signally, and other functions. Although the mechanism by which HGprt deficiency leads to the neurobehavioral abnormalities remains unclear, purines have been shown to influence many aspects of neural function and development. A total of 6 LND iPSC lines and matched normal controls has been generated and characterized already, so they are poised to elucidate mechanism of dysfunction in cerebral cortical and midbrain dopamine neurons.
Emory University is a top-ranked private institution recognized internationally for its outstanding liberal arts colleges, graduate schools, and one of the world's leading healthcare systems. It is located on a beautiful campus in Atlanta, Georgia's historic Druid Hills neighborhood. The area is vibrant with good restaurants and sources of entertainment. Atlanta enjoys rolling hills, a diverse population, and very mild winters.
The successful applicant should be a senior graduate student or recent graduate with a Ph.D. in neuroscience or cell biology. Prior experience with stem cell culture, cell imaging, and/or CRISPR/Cas9 technology is required. Interested individuals should send a brief cover letter, CV, and references and/or letters of recommendation to Dr. Buz Jinnah at firstname.lastname@example.org.