We are seeking an enthusiastic postdoctoral fellow to join our multidisciplinary group dedicated to identifying biomarkers and potential pathogenic cargo from circulating extracellular vesicles after head injury and combat trauma. Protein and RNAs (including microRNAs) are detectable free or in extracellular vesicles (i.e. exosomes ...) in the biological fluids as stable molecules. The aim of this project is to study proteins (via multiplex and ELISA) and RNA (via RNA-seq) detected in circulating exosomes that are enriched for neuronal and astrocyte populations from patients that have experienced traumatic brain injury (TBI) and post-traumatic stress disorder. Our recent data have shown differential levels of proteins in circulating exosomes enriched for neuronal and astrocyte derivation in TBI vs. control subjects.
The objective of the present project is to characterize the protein and RNA cargo in circulating exosomes to develop potential non-invasive biomarkers for TBI and PTSD, and to better understand potential pathological consequences of exosome signaling.
Please send curriculum vitae and contact information for three references to: Victoria Risbrough, Ph.D., Dept. of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0804; e-mail: firstname.lastname@example.org. Successful candidates will be highly motivated and have research experience in biochemistry and/or molecular biology and excellent communication skills. Some experience with extracellular vesicles and bioinformatics related to RNAseq is preferred.