Topic: Transient Receptor Potential (TRP) and mechanosentive Piezo ion channels. We are interested in the mechanism of the regulation of these channels, and their roles in biological processes such as pain, temperature and mechanosensation.
Methods: The successful applicant will apply state-of-the-art molecular, electrophysiological and fluorescence-based tools to investigate the regulation of TRP and/or Piezo channels. Candidates with experience in patch clamp electrophysiology are preferred. Experience in Ca2+imaging, molecular biology and pain related animal behavior is also appreciated.
Lab website: https://rohacslab.org
Liu, L., Yudin, Y., Nagwekar, J., Kang, C., Shirokova, N. & Rohacs, T. Gaq Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation. Journal of Neuroscience 39, 6067-6080, (2019).
Yudin Y, Rohacs T. The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels. Br J Pharmacol. 176(17):3110-3125 (2019)
Badheka, D., Yudin, Y., Borbiro, I., Hartle, C. M., Yazici, A., Mirshahi, T. & Rohacs, T. Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits. Elife 6, e26147, (2017).
Borbiro, I., Badheka, D. & Rohacs, T. Activation of TRPV1 channels inhibit mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Science Signaling 8, ra15, (2015).
How to apply: e-mail CV and the names of three references to: email@example.com
The position requires a Ph.D. degree and relevant research experience. Candidates with experience in patch clamp electrophysiology are preferred. Experience in Ca2+imaging, molecular biology and pain related animal behavior is also appreciated.