Postdoctoral Fellowship - Mechanisms and treatment of dementia- AD & FTD

Location
Atlanta, Georgia
Salary
$50,004 - $56,880
Posted
Sep 25, 2019
Closes
Oct 25, 2019
Position Type
Full Time

Postdoctoral Fellowships available to study mechanisms and promising therapeutic strategies in Alzheimer’s disease & Frontotemporal dementia.

Funded postdoctoral fellowship positions are available in the Kukar Lab at Emory University in the Department of Pharmacology and Chemical Biology and the Center for Neurodegenerative Diseases. The Kukar lab uses a multi-disciplinary approach spanning molecular neuroscience, chemical biology, biochemistry, bioinformatics, induced pluripotent stem cell (iPSCs) and organoid models, and transgenic or CRISPR-KO/KI mouse models to investigate the mechanisms of neurodegeneration. A major focus is to study how autophagy/lysosome dysfunction and neuroinflammation interact to cause Frontotemporal Dementia (FTD) or Alzheimer’s disease (AD).

 This project builds upon recent papers (Holler et al, eNeuro, 2017; Chou et al, Nature Neuroscience, 2018) to understand how decreases in the Progranulin protein and accumulation of RNA-binding proteins (i.e. TDP-43, FUS) cause neurodegeneration. Examples of major projects are to 1) investigate the molecular mechanisms of lysosomal dysfunction and inflammation caused by GRN mutations using iPSC-derived neurons, microglia, and astrocytes, 2) use gene therapy approaches (Adeno-Associated Virus; AAV) to test a novel therapeutic approach to treat FTD, and 3) develop novel transgenic mouse models to characterize lysosome dysfunction in vivo, which will be broadly applicable to understanding Alzheimer’s disease and related dementias.

 Emory has excellent postdoctoral training resources to help advance the careers of post-docs. We are part of the highly-collaborative Emory Center for Neurodegeneration and Chemical Biology Discovery Center and you will have access to state-of-the art equipment and cores to advance your research (https://www.cores.emory.edu/index.html).

 There are multiple opportunities to help advance your career through fellowship and training grants. One opportunity, is the NINDS Training Grant in Translational Research in Neurology. The training will have two principal components: First, fellows will be immersed in an intensive, hands-on laboratory training program; Second, they will learn clinical aspects of neurologic disorders, including current concepts of pathogenesis and pathophysiology, current therapy and potential “targets” for experimental therapeutic intervention (http://www.cnd.emory.edu/training/index.html).

 

 

Application: Please email CV, a personal statement describing interest in position, career goals, and contact info for three references to: tkukar@emory.edu.



Qualifications: A Recent Ph.D. or M.D./Ph.D. in a relevant field (i.e. neuroscience, cell biology, immunology, biochemistry, neuroscience). A track-record of publications and excellent written/verbal communication skills. A background in neuroscience and neurodegeneration is preferred. Experience in molecular biology, biochemistry, cell culture, transgenic animal models, animal surgery, CRISPR/Cas9 techniques, proteomics or human iPSC modeling is a plus, but not required. Fellows are expected to co-author manuscripts, collaborate with lab members, and contribute to the training of new lab recruits.

The successful candidate will be a self-motivated, ambitious, team player that wants to contribute towards human health while having fun doing cutting edge science in the great city of Atlanta!

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