Postdocs dedicated to use scRNA-seq and Patch-clamp to define the cellular constituents of brain

Location
Houston, Texas
Salary
55000
Posted
Aug 27, 2019
Closes
Oct 26, 2019
Position Type
Full Time

The laboratory of Dr. Xiaolong Jiang in the Department of Neuroscience at Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital is seeking applicants for the postdoc research positions. The postdocs will work collaboratively within a multi-disciplinary research team aimed at understanding the cellular constituents of brain circuits in both health and diseases. The specific goals of this position will be to use patch clamp recordings, single-cell RNA-sequencing, machine learning, and sophisticated genetics tools to decipher cellular constituents of brain circuits across cortical areas and species with molecular, electrophysiological, and functional annotations.   

The ideal applicant should have experience in in vitro whole-cell patch recording and/or genetic background with the experience in single-cell RNA-sequencing and bioinformatics analyses of large sequencing datasets, and even developing new bioinformatic methods if necessary. The experience with expertise in both in vitro whole-cell patch recording and genetic background will be first considered. 

You can learn more about our research at https://nri.texaschildrens.org/faculty/xiaolong-jiang-phd and more specific information about the current project in recent publications from out lab:

Jiang X, Shen S, Cadwell CR, Berens P, Sinz F, Ecker AS, Patel S & Tolias AS (2015). Principles of Connectivity among Morphologically Defined Cell Types in Adult Neocortex. Science. Vol. 350 no. 6264 DOI: 10.1126

Cadwell CR,  Palasantza A, Jiang X, Berens B, Deng Q, Yilmaz M, Reimer J, Bethge M,  Tolias KF, Sandberg R and Tolias AS. High-throughput morphological, electrophysiological and transcriptomic profiling  of single neurons. Nature Biotechnology. 2015 Dec 21.3. 

Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis H, Castro J, Tan ZH, Sandberg S, Berens P, Jiang X*, Tolias AT*. Neocortical layer 4 in adult mouse differs in major cell types and circuit organization between primary sensory areas. BioRxiv. 2018, Dec.27; doi: //doi.org/10.1101/507293. Nature Communication. In press *co-corresponding authors

Cadwell CR, Scala F, Fahey PG, Kobak D, Sinz FH, Johnsson P, Li S, Cotton RJ, Sandberg S, Berens P, Jiang X*, Tolias AT*. Cell type composition and circuit organization of neocortical radial clones. BioRxiv. 2019, Jan.23; https://doi.org/10.1101/526681. *co-corresponding authors

 

 



Ph.D. in neuroscience/bioinformatic or related disciplines.The ideal applicant should have experience in in vitro whole-cell patch recording and/or genetic background with the experience in single-cell RNA-sequencing and bioinformatics analyses of large sequencing datasets, and even developing new bioinformatic methods if necessary. The experience with expertise in both in vitro whole-cell patch recording and genetic background will be first considered.

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