Postdoctoral Position in ALS/Neurodegeneration

Location
New York, New York
Salary
Rockefeller University Postdoc
Posted
Nov 05, 2018
Closes
Jan 04, 2019
Position Type
Full Time

The Laboratory of Molecular Biology at The Rockefeller University is seeking a highly motivated and outstanding candidate for a postdoctoral position to study the selective vulnerability and degeneration of upper motor neurons in amyotrophic lateral sclerosis (ALS). ALS presents a paradox in that most known disease-causing mutations are ubiquitously expressed, yet only discrete populations of cells degenerate. We therefore use a multidisciplinary approach, centered on advanced molecular profiling methods to elucidate cell type-specific phenotypes during disease progression in preclinical mouse models and postmortem human tissue. By contrasting vulnerable and resilient neuronal populations as well as non-neuronal cells, we hope to identify novel disease mechanisms and putative entry points for therapeutic intervention These studies are also integrated with modern anatomical and circuit-tracing methods and behavior to map the identity, connectivity, and function of neuronal cell types in cortical and motor circuits.

The ideal candidate will have a Ph.D. in neuroscience or a related field and have prior research experience in molecular or cellular biology. Preference will also be given to those with familiarity with at least one of the following: next generation sequencing, quantitative analysis of sequencing data, animal models of CNS disorders, neuroanatomy and immunohistological methods, and/or functional circuit-mapping. Candidates must also demonstrate a strong track record of research productivity, scientific rigor, excellent communication skills, and an ability to work both independently and as part of a team.

Interested applicants should send a cover letter, CV, and names and contact information of three (3) references to Dr. Eric Schmidt (eschmidt@rockefeller.edu). Applications will be accepted until the position is filled.



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