The laboratory of Troy Ghashghaei is interested in understanding how the brain develops, how it ages, and how during disease or injury these two processes are disturbed. The research projects employ sophisticated and highly interdisciplinary experimental approaches (spanning along a molecular-cellular-tissue-behavior axis) to address fundamental neurobiology questions using the mouse as the model organism. The experimental efforts in the Ghashghaei lab have evolved into three major areas of research: 1. Regulation of developmental transitions in the developing forebrain; The role of ependymal cells in regulation of homeostasis in the forebrain; and 3. Behavioral role of neuronal circuits established during distinct developmental windows.