Our laboratory investigates how the circadian clock imposes a daily rhythmicity to the emergence of adult Drosophila, which serves as a model for understanding how the circadian clock is coupled to physiology and behavior. We recently demonstrated that the circadian rhythm of adult emergence depends on the coupling between circadian pacemaker neurons and the neurons that control the synthesis of the molting hormone, ecdysone (www.nature.com/articles/ncomms15563).
We are offering a postdoctoral position to continue investigating how the circadian clock is coupled to the mechanism that controls the timing of adult emergence. The candidate should ideally have a firm grasp of circadian biology, neurobiology, and Drosophila genetics. And they should be willing to live in Valparaiso, Chile, considered one of the most interesting cities in Chile (see:
The salary will be competitive and based on level of experience. Funding is initially for 1 year, renewable depending on mutual satisfaction.
To apply, please send brief letter explaining your experience and interest in the position, your resume, and the name, phone number, and e-mail of 2 references.
For more information and to apply for the position, please contact:
e-mail: firstname.lastname@example.org / www.cinv.cl/jewer
Centro Interdisciplinario de Neurociencia,
Universidad de Valparaíso. Valparaíso, CHILE
The candidate should ideally have a firm grasp of circadian biology, neurobiology, and Drosophila genetics. And they should be willing to live in Valparaiso, Chile, considered one of the most interesting cities in Chile (https://www.lonelyplanet.com/chile/valparaiso).
Additional Salary Information: The salary will be competitive and based on level of experience. Funding is initially for 1 year, renewable depending on mutual satisfaction.
Regulation of Drosophila behavior by neuropeptides and the circadian clock
We use insect ecdysis to understand how neuropeptides and the circadian clock regulate animal behavior. Ecdysis is the behavior used by all insects to shed the remains of the old exoskeleton at the end of every molt. It is controlled by a number of neuropeptides and hormones, which regulate the precise order and timing o...f the different ecdysial behavioral subroutines. We use the molecular genetic tools available in Drosophila to identify the targets of these neuropeptides and hormones and to understand the contribution of each of these to the behavior; to visualize (using GCaMP, a calcium-sensitive GFP) neural activation during ecdysis; and to understand how this sequential behavior is produced (Mena et al., 2016, eLife). In collaboration with Ben White we have recently examined the response of all the neurons that are targets of ETH (Ecdysis Triggering Hormone), of one of the key neuropeptides that controls ecdysis (Diao et al., 2016, Genetics; Diao et al., 2015, Cell Reports).
The final ecdysis to the adult, also called adult emergence, is controlled by the circadian clock, which restricts emergence to a specific window of time. This “gating” of emergence is known to depend on the activity of the central circadian pacemaker in the brain and on that of a peripheral clock located in the prothoracic gland, which produces the molting hormone, ecdysone. We use genetic approaches in Drosophila to understand how these pacemakers are coupled to produce a daily rhythm of emergence (Selcho et al., 2017, Nature Comm.).