Quantitative histopathology and immunohistochemistry following traumatic brain injury in rats under different levels and types of stress. Neurobehavioral tests of memory, cognition, and anxiety.
The project explores the pathophysiology of how pre-existing stress worsens traumatic brain injury. It also expands upon previous findings that exposure of animals to aeromedical evacuation-relevant hypobaria within several days after traumatic brain injury worsens histologic and neurologic outcomes. Clinically translational neuroprotective interventions will be tested for reducing the effects of stress and hypobaria on brain injury.
Our Neuroprotection Lab is one of at least 15 at the University of Maryland School of Medicine that focuses on traumatic and ischemic brain injury. There are numerous avenues for collaboration and opportunities to learn new animal models and analytical techniques. Our lab consists of other postdocs, PhD students and technical staff. The principal investigator has over 30 years of experience in traumatic and ischemic brain injury research.
A PhD or MD degree with at least 3 years of neuroscience research experience and two first-authored neuroscience research publications. Experience with brain histopathology, and or immunohistochemistry and or rodent neurobehavioral tests is preferred.
Gary Fiskum, Ph.D. received a B.A. in zoology at UCLA and a Ph.D. in Biochemistry at St. Louis University School of Medicine, where he began his research on mitochondria. He continued this line of investigation as a postdoctoral fellow at the Johns Hopkins Univ. School of Medicine under the mentorship of Dr. Albert Lehninger, an internationally famous biochemist and medical educator. In 1981 Dr. F...iskum joined the faculty in the Dept. of Biochemistry at George Washington Univ. School of Medicine where he was tenured in 1987 and promoted to Full Professor in 1991. He moved in 1997 to the Dept. of Anesthesiology at the Univ. of Maryland School of Medicine, where he now serves as the M. Jane Matjasko Professor for Research and the Vice-Chair for Research. His research interests include: adult and pediatric traumatic and ischemic brain injury, mitochondrial bioenergetics, cerebral energy metabolism, oxidative stress, apoptosis, and neuroprotection. Dr. Fiskum has published over 190 original journal articles, reviews and book chapters and is the editor of three books. He and his clinical and basic science collaborators have demonstrated how hyperoxia can be either neuroprotective or detrimental, depending on the form of brain injury and the time during which the injured brain is exposed to hyperoxia. This research resulted in a change in American Heart Association Advanced Cardiac Life Support Guidelines from the long-used indiscriminate use of 100% ventilator oxygen during resuscitation after cardiac arrest to the use of the minimal amount of oxygen necessary to achieve systemic normoxia. Recent work performed in collaboration with engineers at the University of Maryland, College Park has resulted in an animal model of mild traumatic brain injury caused by the intense acceleration experienced by passengers within vehicles targeted by improvised explosive devices. He has organized several international scientific symposia and has mentored numerous students, postdocs and junior faculty. Dr. Fiskum was awarded the prestigious University of Maryland, Baltimore Researcher of the Year Award in 2011. Dr. Fiskum’s research is currently supported by the U.S. National Institutes of Health, the U.S. Army, and the U.S. Air Force.