We are looking for two qualified, motivated and experienced Research Assistant Professors/Post-Doctoral Research Associates to conduct US Army/New Jersey Brain Injury Commission sponsored research. This position is in the Center for Injury Biomechanics, Materials and Medicine (CIBM3) at New Jersey Institute of Technology (NJIT), part of the Institute for Brain and Neuroscience Research (IBNR). The CIBM3 is primarily focused on traumatic brain injury (TBI) including the biomechanics of trauma to neurological outcome. Under the direction of the Principal Investigator, the candidate will engage in research on inhibitory neuronal circuits in brain injury and epilepsy using current electrophysiological and optogenetic modalities, and behavior on experimental rat models. Using cutting-edge technical tools, the candidate will identify fundamental mechanism of blast induced neurotrauma and epileptogenetics. The ideal candidates should demonstrate good work ethics, work independently as well as in a team. This position will also require the ability to manage laboratory personnel, work with students at all levels, and communicate with facilities management, and publish in high quality journals.
Candidates should hold a Ph.D. in Neuroscience or a related discipline or an M.D with research experience and interest in neuronal circuits. The candidate is expected to be proficient in spoken and written English. Prior experience in paired patch-clamp recordings, analysis of network oscillations (in vivo or in vitro) and/or live cell imaging would be valuable. Proficiency in PClamp, familiarity with NIS Elements or other image acquisition/analysis software and, LabView/Matlab, and an interest in computational modeling would be an asset.
Effective communication and writing
Ability to be flexible and adapt to the changing needs of the
Ability to manage multiple
ESSENTIAL FUNCTIONS TO PERFORM:
Conduct experimental blast and blunt injury models, use histology, immunohistochemistry and behavior to identify mechanisms at cellular and tissue levels.
Carry out single and paired, patch-clamp electrophysiology recordings from brain slice preparations in rats.
Undertake analysis of circuit effects of specific neuronal populations using optogenetic activation and photo stimulation in combination with electrophysiological and calcium/voltage-sensitive dye imaging. Studies would include in vitro analysis of microcircuits and network oscillations
Assists with the maintenance of the laboratory facilities, equipment and instruments with a particular emphasis on the electrophysiological systems including confocal microscopes, amplifiers, pullers.
The candidate will be responsible for performing experiments, data analysis and authoring manuscripts. Candidate will maintain records and files of experimental data
Candidates are encouraged to and supported in pursuing research grant opportunities.
Carry out field and patch-clamp electrophysiology recording from brain slice presentations, and use surgery in rats to place electrodes
Perform in vitro and in vivo recordings of electrical activity including network oscillations in rat and mouse brains. Develop protocols to analyze network oscillations.
Performs other related duties as assigned.
Quantitative Western blots, ELISA, Q-RT-PCR
Brain tissue sectioning (vibratome/cryostat) and mounting
Confocal microscopy/digital pathology scanners
Animal surgery including stereotaxic, transcardial perfusion, intracerebral injections
Neural cell cultures, hippocampal slice cultures
Microsoft Office, statistical tools, graph pad software
Using data acquisition hardware
Additional Salary Information: Salary is commensurate to experience and is negotiable